The EnvScore-Aorte Diagnostic Study Protocol for the Identification of Acute Aortic Syndrome
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Acute Aortic Syndrome. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Diagnostic Performance of a Modified AORTAs Score Integrated With Environmental Exposure Data for Acute Aortic Syndrome Identification : The EnvScore-Aorte Diagnostic Study Protocol
Overview
The goal of this retrospective observational study is to evaluate the diagnostic performance of the AORTAs score integrated with environmental exposure data (AORTAs-E) for the identification of Acute Aortic Syndrome (AAS) during initial maangement in the emergency departement. The main question it aims to answer is: Can the integration of real-time meteorological and atmospheric pollution data improve the early identification of AAS in patients presenting in the emergency department for chest, abdominal, or back pain? Researchers will analyze medical records and environmental data for 580 adult patients (290 cases with confirmed AAS and 290 controls) managed at the University Hospital of Besançon between 2014 and 2026. Environmental exposure, including temperature and pollutant concentrations, will be calculated based on each patient's residential address to determine if adding these factors to clinical data increases diagnostic accuracy.
Primary outcome measures
- Area Under the Receiver Operating Characteristic (ROC) Curve (AUC) of the AORTAs scores. [Time frame: From January 2014 to January 2026]
Eligibility criteria
Inclusion Criteria (Cases - AAS+) :
- Adults (>18 years)
- Diagnosis of AAS (aortic dissection, intramural hematoma, or penetrating atherosclerotic ulcer) identified according to medicalization programs for information systems
- Diagnosis confirmed by imaging (CTA, TTE, or TOE)
Inclusion Criteria (Controls - AAS-):
- Adults (>18 years)
- Presenting in the emergency department for chest, back, or abdominal pain.-
- Confirmed differential diagnosis by CTA, ruling out AAS
Exclusion criteria
- Post-traumatic or iatrogenic AAS.
- Subacute (8-30 days) or chronic symptoms (>30 days).
- Patients under legal protection or unable to provide consent/non-opposition.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Case-control
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07467486 · 2025/1012