Image-Guided Central Catheter Insertion With Concurrent Assessment of Vascular Wall Integrity

Peripherally inserted central catheters (PICCs) have been widely used for many years as reliable central venous access devices in patients requiring prolonged intravenous therapy. Traditionally, catheter tip positioning is confirmed using fluoroscopy or chest radiography, which exposes patients to ionizing radiation and may increase procedural time and costs. Technological advances such as the Sherlock 3CG Tip Confirmation System allow real-time catheter navigation and tip positioning using electromagnetic tracking and intracavitary ECG.The primary objective of this prospective single-center clinical study is to evaluate the safety and effectiveness of ultrasound-guided PICC insertion using the Sherlock 3CG system. An additional objective is to assess the effect of PICC placement on venous wall integrity using ultrasound imaging before catheter insertion and after catheter removal.Adult patients (\>18years) with sinus rhythm in the absence of an implanted cardiac pacing device and a medical indication for PICC placement, including chemotherapy, parenteral nutrition, or prolonged intravenous therapy, will be eligible for enrollment. After obtaining written informed consent, patients will undergo pre-procedural ultrasound examination to assess venous anatomy, vessel diameter, and baseline vascular wall characteristics.PICC insertion will be performed under sterile conditions using ultrasound guidance and the Seldinger technique. Cannulation will be performed in one of the upper-arm veins (basilic, brachial, or cephalic vein). Local anesthesia will be administered prior to venipuncture. Catheter tip navigation and positioning at the cavo-atrial junction will be performed using the Sherlock 3CG system with intracavitary ECG guidance.A chest X-ray examination will be performed after each catheter insertion to document the final catheter tip position and to evaluate the accuracy of the Sherlock 3CG system. Fluoroscopic guidance will not be routinely used but will be reserved for cases with suspected anatomical anomalies, previously documented difficult vascular access, or unsuccessful catheter advancement using the standard approach.Procedure duration, success rate, and any intra-procedural or post-procedural complications will be recorded. Following completion of therapy and catheter removal, patients will undergo repeat ultrasound examination to assess venous wall characteristics, including wall thickness, structural changes, and potential complications such as thrombosis or fibrosis. Baseline and follow-up findings will be compared.Participants will be followed according to clinical routine throughout catheter dwell time, and complications such as infection, thrombosis, catheter malfunction, or mechanical issues will be documented.The study will begin on March 1, 2026, with an estimated duration of three years. A total of 80 patients are planned to be enrolled.The results of this study are expected to provide evidence regarding the accuracy and safety of the Sherlock 3CG system, its impact on vascular wall integrity, and its role in optimizing vascular access procedures in clinical practice.

• Accuracy of Catheter Tip Positioning Using Sherlock 3CG [Time frame: Immediately after insertion.]
• Procedural Success Rate [Time frame: During procedure.]
• Procedure Duration [Time frame: Time from skin puncture to successful catheter placement measured in minutes]
• Incidence of Procedure-Related Complications [Time frame: From insertion to 24 hours post-procedure and throughout catheter dwell time.]
• Need for Fluoroscopy Guidance [Time frame: During procedure.]
• Incidence of Endothelial Irregularities [Time frame: Baseline (pre-insertion) to immediately after catheter removal (up to several weeks depending on catheter dwell time).]
• Incidence of Perivascular Edema [Time frame: Baseline (pre-insertion) to immediately after catheter removal (up to several weeks depending on catheter dwell time).]
• Luminal Diameter Changes of the Catheterized Vein Assessed by Ultrasound [Time frame: Baseline (pre-insertion) to immediately after catheter removal (up to several weeks depending on catheter dwell time).]
• Signs of Venous Thrombosis Assessed by Ultrasound [Time frame: Baseline (pre-insertion) to immediately after catheter removal (up to several weeks depending on catheter dwell time).]