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Not yet recruiting NCT07464769

Compression Therapy of Hands and Feet for the Prevention of Taxane- or Oxaliplatin-induced Peripheral Neuropathy

No phase Interventional Peripheral Neuropathy Due to Chemotherapy

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Compression therapy.
Who it may be relevant to
Registry conditions: Peripheral Neuropathy Due to Chemotherapy. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Sweden
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

A Randomized Controlled Study of Compression Therapy of Hands and Feet for the Prevention of Taxane- or Oxaliplatin-induced Peripheral Neuropathy

Overview

Population Cohort 1 Taxane: Breast cancer patients; (neo-)adjuvant treatment Cohort 2 Oxaliplatin: Colorectal cancer patients; (neo-)adjuvant treatment Study design Multicentre, unblinded randomised controlled study Study rationale Chemotherapy-induced peripheral neuropathy is a dose-limiting side effect during treatment and cause persistent impairment and worsening of quality of life in cancer survivors. Compression therapy could be a plausible preventive intervention, although practice changing studies are lacking. Aims To investigate if compression therapy of the hands and feet can reduce the prevalence of both acute and persistent CIPN symptoms caused by taxanes or oxaliplatin. Furthermore, to investigate if compression therapy impact the level of taxane or oxaliplatin dose reductions. Endpoints Primary endpoint * The difference in the occurrence of sensory chemotherapy-induced peripheral neuropathy (CIPN) Selected secondary endpoints * Key secondary endpoint: Difference in relative dose intensity of taxane respectively oxaliplatin. * The difference in the occurrence of motor and autonomic chemotherapy-induced peripheral neuropathy (CIPN). * Difference in occurrence of persistent patient-reported CIPN symptoms 1, 3 and 5 years after start of neurotoxic chemotherapy (EORTC CIPN20) * Health-related quality of life at baseline and after 1, 3, 5 years (EORTC QLQ C30) Exploratory endpoints * Prevalence of autonomic neurotoxicity after neurotoxic treatment, defined as increase of prevalence from baseline to one year after treatment. Substudy • Development of pharmacogenetic risk prediction models of acute respectively persistent taxane induced peripheral neuropathy. Sample size Randomisation 1:1, per site Taxane cohort 268 breast cancer patients, stratification on taxane type Oxaliplatin cohort 90 colorectal cancer patients, stratification on length of treatment Follow-up Patient-reported CIPN symptoms during treatment and at time point up to 5 years post-treatment.

Interventions

  • Other Compression therapy
    Compression garments class 2

Primary outcome measures

  • The difference in the occurrence of sensory chemotherapy-induced peripheral neuropathy (CIPN), defined as the absolute increase from the patient's baseline score in the EORTC CIPN20 sensory PN subscale. [Time frame: This is determined by using the patient's highest reported score from treatment start and up to 6-10 weeks after the final dose (1-24 weeks of treatment).]
Secondary outcome measures (1)
  • Difference in relative dose intensity of taxane respectively oxaliplatin. [Time frame: From start to finish of neoadjuvant or adjuvant treatment, 1-24 weeks.]

Eligibility criteria

Inclusion criteria

o Scheduled neurotoxic treatment in any of the following settings: Taxane cohort

  • Breast cancer patients planned for either neoadjuvant or adjuvant taxane treatment Oxaliplatin cohort
  • Rectal cancer patients planned for total neoadjuvant treatment including oxaliplatin
  • Colorectal cancer patients planned for adjuvant chemotherapy including oxaliplatin, without prior neoadjuvant oxaliplatin treatment
  • Understand written and oral Swedish.

Exclusion criteria

  • Previous neurotoxic chemotherapy\* treatment
  • Distant metastases
  • Any psychiatric disorder or health disorder that causes an inability to make an informed consent to participate.
  • Any manifest clinically significant peripheral neuropathy according to treating physician.
  • Current lymphoedema in limbs requiring compression therapy.
  • Ongoing pregnancy.
  • Planned taxane or oxaliplatin treatment shorter than 8 weeks or longer than 26 weeks
  • Planned compression or cryotherapy of hands and/or feet during taxane or oxaliplatin
  • Taxanes (docetaxel, paclitaxel, nabpaclitaxel), platinum components (carboplatin, oxaplatin, cisplatin), vinca-alkaloids (vincristine, vinblastine, vinorelbine, eribulin), bortezomid, thalidomide, antibody drug conjugate including vedotin or emtansine.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Prevention

Study locations

Sweden · 1 center
  • Linköping University — Jönköping

Identifiers

NCT: NCT07464769 · 2025-08840-01

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗