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Recruiting NCT07464093

STABLE Pilates for Hypermobility

No phase Interventional Ehlers-Danlos Syndrome (EDS) Hypermobile EDS (hEDS) Hypermobile Spectrum Disorder

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Pilates, Education.
Who it may be relevant to
Registry conditions: Ehlers-Danlos Syndrome (EDS), Hypermobile EDS (hEDS), Hypermobile Spectrum Disorder. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Pilates for Hypermobility: A Pilot Feasibility Study

Overview

This study is looking at whether Pilates-based exercise can help with hypermobility-related symptoms, like pain.

Detailed description

In this study, investigators are looking at whether 6 weeks of Pilates-based exercise led by a licensed physical therapist can help with hypermobility-related symptoms, like pain. Pilates is a gentle mind-body exercise with an emphasis on muscular control, postural awareness, and breathing that may be particularly well-suited for managing hypermobility. Exercises are mostly floor-based and focus on developing muscular strength and stability which may improve pain and symptom management.

Interventions

  • Behavioral Pilates
    Pilates is a gentle mind-body exercise with an emphasis on muscular control, postural awareness, and breathing that may be particularly well-suited for managing hypermobility. Exercises are mostly floor-based and focus on developing muscular strength and stability which may improve pain and symptom management
  • Behavioral Education
    Educational seminars pertaining to hypermobility symptom management

Primary outcome measures

  • Intervention Feasibility [Time frame: Enrollment to end of intervention (week 6) and follow-up (week 12)]
  • Acceptability [Time frame: Enrollment to end of intervention (week 6)]
Secondary outcome measures (12)
  • Pain intensity [Time frame: Baseline, week 6 and week 12]
  • Pain interference [Time frame: Baseline, week 6 and week 12]
  • Bristol Questionnaire [Time frame: Baseline, week 6 and week 12]
  • WPI [Time frame: Baseline, week 6 and week 12]
  • PCS [Time frame: Baseline, week 6 and week 12]
  • MAIA-2 [Time frame: Baseline, week 6 and week 12]
  • TSK [Time frame: Baseline, week 6 and week 12]
  • SHS [Time frame: Baseline, week 6 and week 12]
  • Overall physical and mental health [Time frame: Baseline, week 6 and week 12]
  • Heartrate Variability [Time frame: Enrollment to end of intervention (week 6) and follow-up (week 12)]
  • Functional mobility [Time frame: Enrollment to end of intervention (week 6) and follow-up (week 12)]
  • Functional endurance [Time frame: Enrollment to end of intervention (week 6) and follow-up (week 12)]

Eligibility criteria

Inclusion criteria

  • ≥ 18 years old;
  • Self-reported hypermobility with confirmed or suspected diagnosis of hEDS/HSD;
  • Self-reported persistent pain ≥ 3 months;
  • A minimum of 3/10 self-reported pain intensity in the past week
  • Able to get on and off the floor without assistance;
  • Able to communicate fluently in English; and
  • Able to provide written, informed consent

Exclusion criteria

  • Regular ongoing mind-body practice (e.g. Tai chi, yoga, pilates) defined as a regular weekly practice of at least 20min/week over the past 6 months;
  • Recent surgery or acute bone, joint or nerve injury (<6 months);
  • Have a history of a severe or progressive neurological or movement disorder;
  • Pregnant, planning to become pregnant during the study, or currently breast feeding;
  • Unable to get on and off the floor without assistance;
  • Unable to complete study procedures due to cognitive impairment;
  • Unable to provide written, informed consent; or
  • Currently participating in or planning to participate in another physical activity, mind-body or pain-related intervention research study in the next 4 months.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Treatment

Study locations

United States · 1 center
  • Brigham and Women's Hospital — Chestnut Hill

Identifiers

NCT: NCT07464093 · 2026P000203

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗