The Effect of Home and Hospital Mask Designs on Respiratory Variables in Healthy Volunteers
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Non-invasive ventilation (NIV).
- Who it may be relevant to
- Registry conditions: Healthy Volunteers. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Effect of Home and Hospital Mask Designs on Respiratory Variables in Healthy Volunteers: A Pilot Clinical Investigation
Overview
The goal of this randomized cross-over study is to investigate whether the design of non-invasive ventilation (NIV) mask impacts respiratory variables in healthy volunteers on NIV therapy. The main questions it aims to answer are: * To assess if mask design impacts the ventilatory ratio in healthy volunteers. * To assess if mask design impacts transcutaneous CO2, respiratory rate, and tidal volume in healthy volunteers. Participants will attend five study visits: * Visit 1. Participants will be fitted to use non-invasive ventilation briefly to acclimatize them to using the therapy. * Visit 2. Participants will receive NIV with one of four masks. They will be asked to breathe through their mouth or through their nose, with a break from NIV in between the two sessions of NIV. * Visits 3-5. Participants will receive NIV with one of the other three masks, repeating Visit 2.
Detailed description
The study compares breathing with four different NIV masks, the interventional mask and three conventional NIV masks. Participants will be monitored by transcutaneous carbon dioxide, heart rate, oxygen, and respiratory rate monitors.
Participants will attend five study visits:
* Visit 1. Participants will be fitted to use NIV briefly to acclimatize them to using the therapy and ensure the four study masks fit. Participants that fit the masks and tolerate NIV well will be invited to attend four further visits. * Visit 2. Participants will be randomized as to which order they receive the masks, and which order they conduct mouth breathing and nose breathing. Baseline readings of normal unsupported breathing will be taken prior to going on NIV. Participants will the receive NIV with one of four masks for ten minutes and will be instructed to either breathe through their mouth or their nose. There will then be a break from NIV of at least ten minutes until baseline values of respiratory parameters have returned. Then there will be a second ten-minute period of NIV when the participant will be instructed to breathe through the other way through the nose or mouth. Once NIV therapy has been removed the participant will remain attached to the study monitoring equipment until respiratory parameters have returned to normal. * Visits 3-5 are a repeat of Visit 2 with the other study masks. The study is then complete.
Interventions
- Device Non-invasive ventilation (NIV)
Delivery of positive airway pressure to the lungs via an interface, such as a mask
Primary outcome measures
- Change in ventilatory ratio [Time frame: 15 minutes]
Secondary outcome measures (3)
- Change in transcutaneous carbon dioxide (CO2) [Time frame: 15 minutes]
- Change in respiratory rate [Time frame: 15 minutes]
- Change in tidal volume [Time frame: 15 minutes]
Eligibility criteria
Inclusion criteria
- Aged 18 years or over
- Able to give informed consent
Exclusion criteria
- Unable to tolerate non-invasive ventilation (NIV)
- Unable to adequately fit an NIV mask
- Claustrophobia while using NIV
- Symptoms of cold or flu (including COVID-19) in previous twenty-four hours
- Chronic Rhinitis or self-reported history of upper airway obstruction
- Pneumothorax or history of previous pneumothorax
- Employee in the NIV team at Fisher \& Paykel Healthcare
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07463716 · CIA-366 · U1111-1321-2331