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Not yet recruiting NCT07461272

Self-hangIng Patient and Hyperbaric Oxygen Therapy _ SIPHON Study

Phase IV Interventional Suicide

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: OXYGENE MEDICINAL LIQUIDE AIR PRODUCTS MEDICAL.
Who it may be relevant to
Registry conditions: Suicide. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Self-hangIng Patient and Hyperbaric Oxygen Therapy - SIPHON Study / Place de l'Oxygénothérapie Hyperbare Dans la Prise en Charge Des Tentatives de Pendaison

Overview

During an attempted hanging, patients present severe neurological distress that can lead to major neuropsychiatric sequelae. These sequelae are notably due to significant cerebral edema related to hanging. Hyperbaric Oxygen therapy is known to reduce cerebral edema and improve cerebral perfusion. The main objective of the study is to evaluate in patients who have attempted hanging without presenting cardio-respiratory arrest, the effect of one Hyperbaric Oxygen therapy session in addition to standard intensive care management on a potential reduction in short-term neurological sequelae. Patients will benefit from either standard management or standard management associated with one Hyperbaric Oxygen therapy session

Interventions

  • Drug OXYGENE MEDICINAL LIQUIDE AIR PRODUCTS MEDICAL
    In addition to standard intensive care management, patients will receive a hyperbaric oxygen therapy session within eight hours of admission to intensive care (the hyperbaric oxygen therapy session lasts two hours and must be completed eight hours after the hanging attempt).

Primary outcome measures

  • Montreal Cognitive Assessment Score [Time frame: 72 hours plus or minus 6 hours]
Secondary outcome measures (4)
  • Montreal Cognitive Assessment Score [Time frame: Montreal Cognitive Assessment Score at 6 months]
  • Duration of mechanical ventilation [Time frame: Participants will be monitored for duration of mechanical ventilation Participants will be monitored for duration of mechanical ventilation, an expected average of 24 hours]
  • Duration of hospital stay [Time frame: Participants will be monitored for duration of hospital stay, an expected average of 4 days.]
  • Number of adverse events [Time frame: Number of adverse effects during hospitalization, an expected average of 4 days.]

Eligibility criteria

Inclusion criteria

Patients who present, following an attempted hanging, neurological distress defined by the presence of one or more of the following criteria:

  • Glasgow score < 13/15
  • Confusional syndrome
  • Psychomotor agitation Who most of the time require optimal neuroprotection by sedation and invasive mechanical ventilation for the purpose of protecting the airways.
  • Patient aged over 18 years,
  • Suicide attempt by hanging without cardiocirculatory arrest,
  • Patient insured socially and able to understand the information provided

Exclusion criteria

  • Response time exceeded by > 6 hours from the hanging
  • Attempted hanging with immediate return to normal consciousness
  • Refusal of consent from the family or trusted person at the time of inclusion in the study,
  • Patients and/or families unable to understand the information provided

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Treatment

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT07461272 · 2025/0204

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗