Neural Mechanisms of the Social Brain
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Transcranial Magnetic Stimulation (TMS).
- Who it may be relevant to
- Registry conditions: Live Face Processing in Typically Developed Participants. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Neural and Behavioral Correlates of Live Face-to-Face Interactions
Overview
This study aims to understand the neural mechanisms that underlie synchronization of two brains during social interactions.
Detailed description
After being informed about the study and potential risks, all participants giving written informed consent will undergo a structural MRI image for anatomical localization of the targeted stimulation site. Participants will be randomly assigned to one of two TMS target locations, and will be identified for the TMS experiments. Two to three days prior to the TMS experiment, participants will undergo a before TMS/fNIRS experiment. On the day of the TMS experiment participants will undergo a functional dyadic neuroimaging session after TMS stimulation. For the neuromodulation experiments, tDCS, selected sites for stimulation will be identified on the T1 anatomical scans for each participant who will be randomly assigned to one of three groups. In each case the face-gaze fNIRS experiment will be run. Aim 2: Two targeted sites will be confirmed as neural hubs by modification of fiducial neural regions based on the findings of cTBS disruptions. Rationale: These locations and functional specializations are necessary for the proposed neuromodulation tests in the upcoming clinical trial phase.
Part 1: Stimulate to disrupt the site associated with eye-to-eye contact hypothesized to be right superior parietal lobule. Part 2: Stimulate to disrupt the site associated with live face gaze hypothesized to be right supramarginal gyrus.
The focus of this registration is Aim 2.
Interventions
- Device Transcranial Magnetic Stimulation (TMS)
TMS to targeted regions. Transcranial Direct Current Stimulation, tDCS, to targeted and sham regions.
Primary outcome measures
- Percent change in hemodynamic signals [Time frame: Baseline and At time of measurement, approximately one hour]
- Electroencephalography (EEG) response to live face gaze [Time frame: At time of measurement, approximately one hour]
- Eye Contact Behavior [Time frame: At time of measurement, approximately one hour]
- Face Gaze Behavior [Time frame: At time of measurement, approximately one hour]
Eligibility criteria
Inclusion criteria
-Self reported typically developed adults.
Exclusion criteria
-No prior history of seizure activity. Self reported absence of recreational drugs at time of study.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Basic science
Study locations
United States · 1 center
- Yale School of Medicine — New Haven
Identifiers
NCT: NCT07457567 · 1501015178 · 1R61MH138705-01