Menu
Recruiting NCT07455461

Cortical Excitability During de Novo Motor Learning

No phase Interventional Motor Learning Corticospinal Excitability

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: De novo motor learning.
Who it may be relevant to
Registry conditions: Motor Learning, Corticospinal Excitability. Basic parameters: 18 years — 35 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
France
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Cortical Excitability During de Novo Motor Learning in Healthy Subjects : an Exploratory Longitudinal Study

Overview

De novo motor learning is a specific learning paradigm that allows investigation of how a new motor skill is learned from scratch. Motor task learning can induce increased corticospinal excitability and reorganization of connectivity observed within the motor cortex (M1). Several studies have investigated the plasticity mechanisms underlying motor learning using simple paradigms. The results obtained have been variable, with a major trend toward increased corticospinal excitability, while other results show no increase. We expect to observe a significant increase in excitability and enhanced intracortical reorganization mechanisms within M1 in our subjects during our de novo motor learning sessions. The primary objective of this study is to measure changes in corticospinal excitability of the motor system across 3 de novo motor learning sessions separated by different time intervals. The secondary objectives will be: 1) to measure learning across the three practice sessions, 2) to measure changes in inhibition and facilitation across the 3 learning sessions, and 3) to measure correlations between subjects' motor performance and corticospinal and intracortical changes.

Interventions

  • Behavioral De novo motor learning
    Subjects will follow 3 sessions of de-novo motor learning (days 1, 2, 8)

Primary outcome measures

  • Change in Motor Evoked Potential (MEP) Amplitude Input-Output Curve Assessed by Single-Pulse TMS [Time frame: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9]
  • Change in Short-Interval Intracortical Inhibition (SICI) Assessed by Paired-Pulse TMS [Time frame: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9]
  • Change in Long-Interval Intracortical Inhibition (LICI) Assessed by Paired-Pulse TMS [Time frame: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9]
  • Change in Intracortical Facilitation (ICF) Assessed by Paired-Pulse TMS [Time frame: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9]
Secondary outcome measures (1)
  • Change in Motor Learning Performance Assessed by Movement Path Length During a 3D Finger-Cursor Task [Time frame: During each motor learning session on Day 1, Day 2, and Day 9]

Eligibility criteria

Inclusion criteria

  • right-handed
  • healthy
  • having signed an informed consent form

Exclusion criteria

  • counter-indication to transcranial magnetic stimulation
  • pregnancy

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Basic science

Study locations

France · 1 center
  • Eurasport — Loos

Identifiers

NCT: NCT07455461 · 2023-A02139-36

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗