Menu
Enrolling by invitation NCT07453758

Nurse and Peer Led Suicide Prevention in Tajikistan

No phase Interventional Suicide Ideation

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Suicide prevention treatment, Care as usual.
Who it may be relevant to
Registry conditions: Suicide Ideation. Basic parameters: 18 years — 59 years · Female.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Tajikistan
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

The study takes place in Tajikistan, a postwar country in Central Asia, where Dr. Weine, Dr. Pirova, Dr. Bahromov, and other collaborators successfully implemented a D43 research capacity building project and an R21 and R01 on stepped care for women's mental health in primary care. This study also builds on the team's prior research that demonstrated the effectiveness of nurse- and peer-led interventions, identified risk and protective factors for suicide among women, and on the PREVAIL peer-led suicide prevention model. The specific aims for this new project are: Aim 1: Adapt the evidence-based PREVAIL model into a new SUSTAIN nurse- and peer-led suicide prevention model in primary care for women at moderate or high suicide risk in rural and urban Tajikistan using a participatory co-design process (the Transcreation Framework) with multi-level partners. Aim 2: Evaluate a pilot implementation of the SUSTAIN model in primary care among 96 women with moderate to high suicide risk, 48 randomized to SUSTAIN and 48 to an enhanced usual care condition, with both groups followed for 9 months for suicidal ideations or behaviors, mental health outcomes, and mediators. Aim 3: Assess the acceptability, feasibility, appropriateness, potential for scalability and sustainability, programmatic costs, and partnership of SUSTAIN to inform a future hybrid type 2 effectiveness-implementation pragmatic trial.

Interventions

  • Behavioral Suicide prevention treatment
    SUSTAIN intervention is a nurse and peer-led individual, group and family sessions suicide prevention intervention. There are 9 sessions that are attended by the women (6 individual and 3 group) and 1 session that is attended by their family members; this will occur over the course of 8-12 weeks depending on timing and scheduling.
  • Behavioral Care as usual
    Enhanced usual care (EUC) control condition): In the 6 clinics assigned to the control condition, the women who screen positive for moderate to high suicide risk will receive enhanced usual care. They will be evaluated by a family medicine doctor who will confirm their level of risk and decide on appropriate actions. This could include an admission to inpatient psychiatry, a referral to outpatient psychiatry, or management in the family medicine clinic which may include counseling, psychiatric

Primary outcome measures

  • Columbia Suicide Severity Rating Scale [Time frame: Baseline and 3, 6, 9 months post intervention]
Secondary outcome measures (12)
  • Medically serious suicide attempts [Time frame: 3, 6, and 9 months post intervention]
  • Suicide Cognitions Scale-Short Form (SCS-S) [Time frame: 3, 6, and 9 month post intervention]
  • Beck Hopelessness Scale (BHS) [Time frame: 3, 6, 9 months post intervention]
  • Brief Reasons for Living (BRFL) [Time frame: 3, 6, 9 month post intervention]
  • Patient Health Questionnaire-9 (PHQ-9) [Time frame: 3, 6, 9 month post intervention]
  • Generalized Anxiety Disorder-7 (GAD-7) [Time frame: 3, 6, 9 months post intervention]
  • PTSD CheckList - Civilian Version (PCL-C) [Time frame: 3, 6, 9 months post intervention]
  • Abuse Assessment Screen [Time frame: 3, 6, 9 month post intervention]
  • Pearlin Mastery Scale [Time frame: 3, 6, 9 months post intervention]
  • Mental Health Knowledge Schedule (MAKS) [Time frame: 3, 6, 9 months post intervention]
  • Short Form Health Survey (SF-12) [Time frame: 3, 6, 9 months post intervention]
  • Interpersonal Needs Questionnaire (INQ) [Time frame: 3, 6, 9 months post intervention]

Eligibility criteria

Inclusion criteria

  • Tajik women age 18 to 59 who meet operationally defined criteria for moderate or high risk suicide risk. We will identify women at-risk for suicide defined as:
  • a recent suicide attempt (past 3 months)
  • recent suicidal ideation that is accompanied by either a plan or intention as assessed by the Columbia-Suicide Severity Rating Scale (C-SSRS). If they score a level 2 or higher on the C-SSRS, they are eligible. Level 2 refers to non-specific active suicidal thoughts. At level 2, a person has general, active thoughts of wanting to end their life but has not formulated a specific plan, method, or intention to act on them.

Other inclusion criteria are: 1) willing to participate in the SUSTAIN intervention and research procedures; and 2) able to give written informed consent.

Exclusion criteria

  • If they score less than a level 2 on the C-SSRS they are not eligible

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Prevention

Study locations

Tajikistan · 1 center
  • PRISMA research center — Dushanbe

Identifiers

NCT: NCT07453758 · 2025-0021 · R34MH136247

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗