Cognitive Disengagement Syndrome in Functional Neurological Symptom Disorder
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Functional Neurological Symptom Disorder. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Symptoms of Sluggish Cognitive Tempo/Cognitive Disengagement Syndrome in Functional Neurological Symptom Disorder/Conversion Disorder: A Cross-Sectional Case-Control Study
Overview
This cross-sectional observational case-control study aims to investigate symptoms of sluggish cognitive tempo (SCT), also known as cognitive disengagement syndrome (CDS), in adults diagnosed with Functional Neurological Symptom Disorder/Conversion Disorder (FNSD/CD). The study compares SCT/CDS symptoms between patients with FNSD/CD and healthy controls and evaluates their relationship with clinical variables. It is hypothesized that individuals diagnosed with FNSD/CD will exhibit higher levels of SCT/CDS symptoms compared to healthy controls.
Detailed description
Sluggish Cognitive Tempo (SCT), also referred to as Cognitive Disengagement Syndrome (CDS), is characterized by symptoms such as excessive daydreaming, mental fogginess, lethargy, slowed behavior, confusion, and reduced alertness. Research indicates that SCT/CDS symptoms are distinct from attention deficit hyperactivity disorder (ADHD), although some overlap may occur. Studies suggest that SCT/CDS may be influenced more by environmental and neurocognitive factors than by heritability.
Functional Neurological Symptom Disorder (FNSD), also known as Conversion Disorder (CD), is characterized by neurological symptoms that cannot be explained by an identifiable neurological disease. These symptoms may include motor dysfunction (weakness, tremor, gait abnormalities), non-epileptic seizures, sensory disturbances, or mixed presentations. Although symptoms are not attributable to structural neurological pathology, they cause significant functional impairment.
The etiology of FNSD remains unclear. Proposed mechanisms include altered functional connectivity between emotional processing networks and motor/sensory regions, impaired memory and attention processing, and stress-related neurobiological dysregulation. Neurocognitive models suggest that attention and memory impairments may be present in individuals with FNSD, particularly under stress.
Despite increasing research on SCT/CDS in ADHD and other psychiatric conditions, SCT/CDS symptoms have not been systematically studied in adults with FNSD. Considering the hypothesized cognitive and attentional involvement in FNSD, SCT/CDS symptoms may be present in this population.
This study is designed as a cross-sectional case-control study conducted at the Psychiatry Outpatient Clinic of Elazığ Mental Health and Diseases Hospital. Participants will include adults aged 18-65 years diagnosed with FNSD according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision criteria and a matched healthy control group without psychiatric diagnoses.
Participants will complete a sociodemographic and clinical information form and validated psychometric scales, including: Barkley's Adult Sluggish Cognitive Tempo Scale (Turkish version), Somatoform Dissociation Questionnaire, Adult ADHD Self-Report Scale. No invasive or interventional procedures will be performed. Group comparisons will be conducted using appropriate parametric or non-parametric tests. Correlation and regression analyses will be performed when necessary. Statistical significance will be defined as p ≤ 0.05. Power analysis indicates that a minimum of 24 participants per group (total n=48) is required to achieve 80% power at alpha=0.05.
Primary outcome measures
- Barkley's Adult Sluggish Cognitive Tempo Ratings Scale -Turkish Version (SCT) [Time frame: At hospital admission (baseline)]
- Somatoform Dissociation Questionnaire (SDQ-20) [Time frame: At hospital admission (baseline)]
Secondary outcome measures (1)
- Adult ADHD Self-Report Scale (ASRS) [Time frame: At hospital admission (baseline)]
Eligibility criteria
- Inclusion Criteria for the Functional Neurological Symptom Disorder (FNSD) Group:
- Meeting the diagnostic criteria for FNSD/CD according to DSM-5-TR at the time of admission
- Being between 18-65 years of age
- Absence of additional psychiatric disorders
- Absence of alcohol/substance use disorder
- Absence of neurological disorders affecting cognition
- Being in remission with FNSD/CD
- Completing sociodemographic data fully
- Willingness to complete the forms and scales.
- Willingness to participate in the study
- Exclusion Criteria for the FNSD Group:
- Being under 18 or over 65 years of age
- Not meeting the diagnostic criteria for FNSD/CD according to DSM-5-TR
- Active alcohol/substance use
- Having neurological diseases affecting cognitive functions (such as Alzheimer's disease, delirium, Parkinson's disease)
- Not being willing to participate in the study
- Incomplete sociodemographic data
- Not being willing to complete forms and scales.
- Inclusion Criteria for the Healthy Control (HC) Group
- Being between 18-65 years of age
- Not having any psychiatric disorder
- Not having an alcohol/substance use disorder
- Not having a neurological disorder affecting cognition
- Completing sociodemographic data in full
- Being willing to complete the forms and scales.
- Being willing to participate in the study
- Exclusion Criteria for the HC Group:
- Being under 18 or over 65 years of age
- Having a psychiatric disorder
- Active alcohol/substance use
- Having neurological diseases affecting cognitive functions (such as Alzheimer's disease, delirium, Parkinson's disease)
- Not being willing to participate in the study
- Incomplete sociodemographic data
- Not being willing to complete forms and scales.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
Turkey (Türkiye) · 1 center
- Elazığ Mental Health and Diseases Hospital Psychiatry Clinic — Elâzığ
Identifiers
NCT: NCT07451821 · EMHDH-2026-FNSD-SLUGGISHTEMPO