Retrospective Analysis of Acute Pancreatitis After Percutaneous Mechanical Thrombectomy In Treatment Of Thrombotic Disorders
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Acute Pancreatitis (AP), Thrombotic Disorders. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Retrospective Analysis of Acute Pancreatitis After Percutaneous Mechanical Thrombectomy In Treatment Of Thrombotic Disorders (The RATIO Study)
Overview
Acute pancreatitis is a rare complication after percutaneous mechanical thrombectomy in treatment of thrombotic disorders. The objectives of this study include: (1) Determine the incidence and severity of acute pancreatitis after percutaneous mechanical thrombectomy; (2) Identify patient/procedural risk factors; (3) Evaluate clinical outcomes; (4) Develop a diagnosis and treatment pathway.
Detailed description
Percutaneous mechanical thrombectomy (PMT) has seen increasing utilization in the management of acute thrombotic events within both arterial and venous systems. The rheolytic thrombectomy such as AngioJet system employs hydrodynamic principles to disrupt and remove thrombus. The efficacy and safety have been demonstrated across various vascular diseases, including deep venous thrombosis (DVT), peripheral arterial occlusions, and dialysis access thrombosis, establishing PMT as a valuable minimally invasive therapeutic option. Acute pancreatitis is a serious inflammatory condition commonly associated with gallstones, alcohol consumption, hyperlipidemia, or metabolic disorders. Only isolated case reports have documented this complication following PMT. Despite the well-documented occurrence of other procedure-related adverse events, such as bradycardia, hemoglobinuria, and renal impairment, pancreatitis remains an exceptionally rare and under-recognized complication. The objectives of this study include: (1) Determine the incidence and severity of acute pancreatitis after percutaneous mechanical thrombectomy; (2) Identify patient/procedural risk factors; (3) Evaluate clinical outcomes; (4) Develop a diagnosis and treatment pathway.
Primary outcome measures
- Incidence of acute pancreatitis [Time frame: Within 14 days]
Secondary outcome measures (1)
- Incidence of acute severe pancreatitis [Time frame: Within 14 days]
Eligibility criteria
Inclusion criteria
- Patients over 18 years old;
- Patients with thrombotic peripheral vascular diseases treated by percutaneous mechanical thrombectomy;
- Patients developed acute pancreatitis within 14 days after percutaneous mechanical thrombectomy;
- Patients with written informed consent.
Exclusion criteria
- Patients with acute pancreatitis attributed to other confirmed causes;
- Patients unable or unwilling to participate in the study.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Renji Hospital — Shanghai
Identifiers
NCT: NCT07450898 · The RATIO Study