Machine Learning Prediction of Mortality After Prone Positioning in ARDS
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Prone Position Ventilation.
- Who it may be relevant to
- Registry conditions: Acute Respiratory Distress Syndrome (ARDS), Prone Position Ventilation, Machine Learning, ICU. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
A Machine Learning Model to Predict Mortality in Patients With Acute Respiratory Distress Syndrome After Prone Positioning
Overview
Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality. Prone position ventilation (PPV) is an evidence-based therapy that improves oxygenation and survival in patients with moderate to severe ARDS; however, outcomes remain heterogeneous. Early identification of patients at high risk of mortality after PPV may improve clinical decision-making and individualized management. This retrospective observational study aims to develop and validate a machine learning model to predict intensive care unit (ICU) mortality in ARDS patients receiving prone position ventilation. Clinical, laboratory, and treatment variables collected from ICU electronic medical records will be used to construct prediction models using multiple machine learning algorithms. The performance of these models will be evaluated and compared to identify the optimal model for mortality prediction.
Interventions
- Other Prone Position Ventilation
Prone position ventilation applied as part of routine clinical care for patients with acute respiratory distress syndrome. No experimental intervention was assigned in this observational study.
Primary outcome measures
- ICU Mortality [Time frame: Up to 90 days.]
Eligibility criteria
Inclusion criteria
- Diagnosis of ARDS according to the Berlin definition \[15\];
- Receipt of at least one session of prone position ventilation (PPV) during hospitalization;
- Requirement for mechanical ventilation.
Exclusion criteria
- Age <18 years;
- PPV duration <6 hours;
- ICU length of stay <24 hours;
- Pregnancy;
- Missing key clinical data.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07445061 · B2026-019