Targeted Nerve Injection to the Knee (Nerve to Vastus Medialis): Comparing Two Adductor Canal Block Approaches
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Traditional adductor canal block, NVM (nerve to vastus medialis) targeted adductor canal block, Chloroprocaine Injection.
- Who it may be relevant to
- Registry conditions: Anesthesia, Local. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Study of Targeted Injection of Nerves to the Knee-A Volunteer Trial Evaluating Nerve to Vastus Medialis
Overview
This randomized, double-blinded volunteer study compares two ways of performing the adductor canal (AC) nerve block at the mid-thigh to see which approach more reliably numbs the anteromedial knee. One approach is the traditional AC block placed near the saphenous nerve; the other separately targets the nerve to vastus medialis (NVM) in addition to the saphenous nerve. Healthy adult participants receive both blocks in one visit (one on each leg), with the order randomized. The primary outcome is change in quadriceps strength (a proxy for vastus medialis anesthesia) measured by load-cell dynamometry. Secondary outcomes include cutaneous sensory mapping (pinprick and cold) and the percentage of a standardized, marked knee-incision line covered by sensory block. The study uses ultrasound guidance and a standard dose of chloroprocaine, with routine monitoring to minimize risks.
Interventions
- Procedure Traditional adductor canal block
Ultrasound-guided injection adjacent to the saphenous nerve; 20 mL of 2% chloroprocaine. - Procedure NVM (nerve to vastus medialis) targeted adductor canal block
Ultrasound-guided injection; 10 mL 2% chloroprocaine at the NVM (confirmed by nerve stimulation), plus 10 mL at the saphenous nerve. - Drug Chloroprocaine Injection
2% chloroprocaine
Primary outcome measures
- Quadriceps strength as measured by load cell dynamometer [Time frame: Day 1]
Secondary outcome measures (1)
- Percentage of hypothetical incision covered [Time frame: Day 1]
Eligibility criteria
Inclusion criteria
- Age ≥18 years
- Able to provide written informed consent
- Able and willing to comply with study procedures and \~6-hour visit
- American Society of Anesthesiologists (ASA) Physical Status 1 or 2
- Weight >70 kg
Exclusion criteria
- BMI >35 kg/m²
- Use of analgesics within 24 hours before the procedure
- History of thigh trauma or surgery
- Pregnant or planning pregnancy
- Lower extremity deformities/tattoos interfering with block performance
- Systemic neuromuscular disease
- Contraindications to regional anesthesia (e.g., infection, allergy, challenging sonoanatomy)
- Other health conditions that would affect safe participation
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Triple blind
- Primary purpose
- Basic science
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07444827 · PRO00119256