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Enrolling by invitation NCT07444736

Effect of 8 Weeks of Resistance Training With Blood Flow Restriction on Muscle Strength, Clinical Parameters, Biochemical Biomarkers, and Perceived Exertion in Adults With Obesity

No phase Interventional Obesity & Overweight

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Intervention, Intervention.
Who it may be relevant to
Registry conditions: Obesity & Overweight. Basic parameters: 18 years — 30 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Mexico
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Overview

To analyze the effect of 8 weeks of resistance training with blood flow restriction on muscle strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity.

Detailed description

Resistance training has been demonstrated to be an effective intervention for improving muscular strength and metabolic profile. According to the available evidence, a moderate-to-high intensity level (60-90% of one-repetition maximum \[1RM\]) is required to achieve optimal outcomes in healthy adults.

Blood flow restriction (BFR) training, in turn, has emerged as an innovative strategy that promotes gains comparable or similar to those achieved with moderate-to-high intensity resistance training. It has been proposed as an efficient and safe training alternative in both clinical and non-clinical settings . Current findings identify BFR as a promising, versatile, accessible, and particularly useful tool when moderate-to-high intensity resistance training must be limited or contraindicated.

Therefore, the present study aims to evaluate the effects of 8 weeks of resistance training combined with blood flow restriction on muscular strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity, providing evidence regarding a potentially safe and effective intervention.

Interventions

  • Other Intervention
    The BFR group will perform machine-based quadriceps extension exercises and dumbbell biceps curls involving both lower limbs and both upper limbs. Each exercise will consist of 4 sets of 12 repetitions. Quadriceps extensions will be performed at an intensity of 40% of one-repetition maximum (1RM), and biceps curls at 20% of 1RM. The execution cadence will be standardized to 1 second for the concentric phase and 2 seconds for the eccentric phase. Inter-set rest intervals will be 1 minute. For vas
  • Other Intervention
    The control group will perform quadriceps extensions and biceps curls, completing 4 sets of 10 repetitions at an intensity of 70% of one-repetition maximum (1RM). The execution tempo will be standardized to 1 second for the concentric phase and 2 seconds for the eccentric phase, with 2-minute inter-set rest intervals. The protocol will adhere to the resistance training guidelines established by the American College of Sports Medicine (ACSM)

Primary outcome measures

  • Muscle strength [Time frame: Baseline and after 8 weeks]
  • Dynamic muscle strength [Time frame: Baseline and after 8 weeks]
  • Arm circumference [Time frame: Baseline and after 8 weeks]
  • Thigh circumference [Time frame: Baseline and after 8 weeks]
  • Maximum oxygen uptake (VO₂max) [Time frame: Baseline and after 8 weeks]
  • Systolic blood pressure (SBP) [Time frame: Baseline and after 8 weeks]
  • Diastolic blood pressure (DBP) [Time frame: Baseline and after 8 weeks]
  • Heart rate [Time frame: Baseline and after 8 weeks]
  • Glucose [Time frame: Baseline and after 8 weeks]
  • Triglycerides [Time frame: Baseline and after 8 weeks]

Eligibility criteria

Inclusion criteria

  • Adults aged 18 to 40
  • Both genders
  • BMI ≥ 30 kg/m\^2 and < 40 kg/m\^2
  • Signed informed consent form

Exclusion criteria

  • Participants who smoke
  • Personal and family history of vascular disease or deep vein thrombosis
  • Clinical diagnosis of hypothyroidism
  • Clinical diagnosis of type 1 diabetes mellitus
  • Clinical diagnosis of type 2 diabetes mellitus
  • Clinical diagnosis of grade 3 obesity
  • Clinical diagnosis of hypertension
  • Clinical diagnosis of acute myocardial infarction or angina pectoris
  • Use of nitrates and calcium channel blockers within 4 days prior to the start of the study
  • Use of anticoagulants
  • Use of beta-blockers or hypoglycemic agents within 7 days prior to the intervention
  • Pregnant women
  • Breastfeeding women
  • Men consuming more than 40 g of alcohol per day or women consuming more than 20 g per day
  • Postural and biomechanical disorders (knee, foot, and spine)

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Treatment

Study locations

Mexico · 1 center
  • Centro Universitario de Tlajomulco — Tlajomulco de Zúñiga

Identifiers

NCT: NCT07444736 · CUTLAJO260219

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗