Effect of Resistance Exercise on Energy Balance and Appetite Regulation in Males and Females
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: resistance exercise (males), resistance exercise (females).
- Who it may be relevant to
- Registry conditions: Energy Balance, Energy Expenditure, Males and Females, Resistance Exercise. Basic parameters: 20 years — 30 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Taiwan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
There is growing evidence that males and females may exhibit different acute responses and long-term adaptations to exercise training. Accordingly, contemporary exercise physiology research increasingly recognizes sex as an important biological variable that may influence appetite regulation and energy balance. This year's project aims to investigate: (1) appetite regulation and energy balance following acute resistance exercise, and (2) potential sex-based differences in appetite regulation and energy balance in response to resistance exercise. Understanding both the overall effects of resistance exercise and sex-related variability in these responses is important for improving the physiological interpretation of exercise-induced changes in appetite and energy balance. Such knowledge may help to reduce heterogeneity in exercise research findings and support the development of more precise, evidence-based exercise prescriptions that are applicable to both males and females.
Interventions
- Other resistance exercise (males)
Resistance exercises are in the following order: squat, bench press, deadlift. Each exercise consists of 3 sets with 7 repetitions, using a load of 70% 1RM with 120 sec of rest between sets. - Other resistance exercise (females)
During the early follicular phase, participants completed a standardized resistance exercise protocol consisting of squat, bench press, and deadlift, performed in a fixed order. Each exercise comprised three sets of seven repetitions at 70% of one-repetition maximum (1RM), with 120 s of rest between sets.
Primary outcome measures
- Subjective appetite [Time frame: 3 hours during each study intervention]
- Change in acyl-Ghrelin [Time frame: 3 hours during each study intervention]
- Change in PYY [Time frame: 3 hours during each study intervention]
- Change in lactate [Time frame: 3 hours during each study intervention]
- Energy intake [Time frame: The Before day, the durning day, and the day following the experiment.]
- change in Cortisol [Time frame: 3 hours during each study intervention]
- Energy expenditure [Time frame: The Before day, the durning day, and the day following the experiment.]
- Energy Balance [Time frame: The Before day, the durning day, and the day following the experiment.]
Secondary outcome measures (12)
- Leeds food preference questionnaire [Time frame: 3 hours during each study intervention]
- Leeds food preference questionnaire [Time frame: 3 hours during each study intervention]
- 10 Ratings of Perceived Exertion (RPE) [Time frame: 1-hour during each exercise intervention]
- Heart rate (HR) [Time frame: 3-hour during each study intervention]
- Estradiol (E2) [Time frame: Baseline for each trial (female participants only).]
- Progesterone (P4) [Time frame: Baseline for each trial (female participants only).]
- Concentric Peak Velocity [Time frame: During each exercise condition.]
- Concentric Mean Velocity [Time frame: During each exercise condition]
- Eccentric Peak Velocity [Time frame: During each exercise condition]
- Concentric Mean Power [Time frame: During each exercise condition]
- Relative Concentric Mean Power [Time frame: During each exercise condition]
- Concentric Work [Time frame: During each exercise condition]
Eligibility criteria
Inclusion criteria
- Healthy males and females aged 20-30 years
- Females with a regular menstrual cycle
- Stable body weight, defined as no significant change in body weight during the past 6 months
- Willingness to participate and provide written informed consent
Exclusion criteria
- Obesity, defined as:
- Body mass index (BMI) > 30 kg/m²
- Body fat percentage > 25% in males
- Body fat percentage > 30% in females
- Hypertension, defined as resting blood pressure > 140/90 mmHg
- History of cardiovascular disease
- History of cancer
- History of liver disease
- History of kidney disease
- Presence of any medical condition that may interfere with study outcomes
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Taiwan · 1 center
- National Taiwan Normal University — Taipei
Identifiers
NCT: NCT07444021 · 202412HM018