Older Age and Generalization
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Memory decision type.
- Who it may be relevant to
- Registry conditions: Aging. Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effects of Older Age on the Neural Basis of Memory Generalization
Overview
The goal of this clinical is to learn how the brain supports different kinds of memory decisions in healthy young and older adults. The main question it seeks to answer is: Do older adults make memory decisions by integrating across experiences? Young (aged 18-30 years) and older (aged 65-80 years) participants will complete a memory task while undergoing functional MRI to measure their brain responses. Researchers will compare brain measures of integration in older adults to those of young adults to see if integration increases in older age.
Interventions
- Behavioral Memory decision type
Subjects will be probed to either remember an association they saw directly during the study phase or to make an inference across indirectly associated items.
Primary outcome measures
- Behavioral memory responses [Time frame: Session 2 (experimental session)]
- Neural memory responses [Time frame: Session 2 (experimental session)]
Eligibility criteria
Inclusion criteria
- Either aged 18-30 years (young adults) or aged 65-80 years (older adults) (self-report)
- Fluent in English (self-report)
- Right-handed (self-report)
- Cognitively healthy (self report verified by score > 24 on Montreal Cognitive Assessment)
- Self-reported normal or corrected-to-normal vision
Exclusion criteria
- Self-reported neurological disorder (e.g., Alzheimer's or Parkinson's disease)
- Self-reported uncontrolled hypertension, diabetes, or thyroid disorder
- Having conditions or devices that are unsafe for MRI (assessed via imaging center's MRI safety screening form)
- Self-reported difficulty lying still on one's back for 1-2 hours
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 1 center
- University of Wisconsin-Milwaukee — Milwaukee
Identifiers
NCT: NCT07440017 · 23.108 · R01AG098263