The Effects of One Day of Activity on the Next Day's Exercise Response
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Decreased step count.
- Who it may be relevant to
- Registry conditions: Inactivity, Physical. Basic parameters: 18 years — 30 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
A Single Day of Inactivity on the Systemic Metabolic and Inflammatory Exercise Response
Overview
Exercise can reduce the risk of several chronic diseases. However, recent studies have suggested sitting for too long before exercising can decrease exercise benefits. This study will help determine why this may occur.
Detailed description
Previous work demonstrated a greater utilization of carbohydrates (CHO) at the end of aerobic exercise with a day of reduced activity (\<5,000 steps). Additionally, there are differences in the RNA profile at rest and during exercise in pathways related to inflammation, metabolism, and innate immunity that warrant further research. Together, these data highlight that a single day of reduced activity alters systemic homeostasis that affects the exercise response. Given the potency of exercise to ameliorate risk of cardiovascular disease, more research is needed to find factors to augment the exercise response. Therefore, this study has two goals: 1) Analyze circulating metabolomics, and 2) metabolomics and proteomics in response to exercise after a day of reduced activity.
Interventions
- Behavioral Decreased step count
Subjects will walk less than 5,000 steps
Primary outcome measures
- Concentration of metabolites within the plasma [Time frame: Participants will complete the study within 6 weeks of enrollment.]
- Concentration of proteins within the plasma [Time frame: Participants will complete the study within 6 weeks of enrollment.]
Eligibility criteria
Inclusion criteria
- • between the ages of 18-30 years old
Exclusion criteria
- • free from acute or chronic illness (cardiac, pulmonary, liver, or kidney abnormalities, cancer, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other known metabolic disorders)
- do not take medications related to metabolism (i.e., statins, metformin, GLP-1 agonists)
- free from orthopedic limitations (including any artificial joints)
- currently smoke or participate in other forms of tobacco use.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
United States · 1 center
- Concordia University of Wisconsin — Mequon
Identifiers
NCT: NCT07429370 · https://pubmed.ncbi.nlm.nih.go · 26BAIREA1560979