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Recruiting NCT07426549

Close Chain and Open Chain Exercises With Blood Flow Restriction in Knee Osteoarthritis

No phase Interventional Knee Osteoarthristis

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Closed kinetic chain exercises with blood flow restriction, Open kinetic chain exercises with blood flow restriction.
Who it may be relevant to
Registry conditions: Knee Osteoarthristis. Basic parameters: 45 years — 75 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Pakistan
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Comparison of Close Chain and Open Chain Exercises With Blood Flow Restriction in Knee Osteoarthritis

Overview

The aim of this research is to find and compare the effect of close chain and open chain exercises with blood flow restriction in knee osteoarthritis on pain, range of motion, strength and functional performance in patients with knee osteoarthritis. Randomized controlled trials done at Railway General Hospital and Medistic Medical and Dental Center, Rawalpindi. The sample size was 40. The subjects were divided in two groups, 20 subjects in close chain exercises with blood flow restriction group and 20 in open chain exercises with blood flow restriction group. Study duration was of 4 weeks. Sampling technique applied was purposive non probability sampling technique. Only 45-75 years individual with grade 1 or 2 knee osteoarthritis were included. Tools used in the study are Numeric pain rating scale (NPRS), Western Ontario and McMaster Universities Arthritis Index (WOMAC), goniometer, crane scale (dynamometer), 30 s chair stand test. Data was analyzed through SPSS 21.

Interventions

  • Other Closed kinetic chain exercises with blood flow restriction
    Closed kinetic chain exercises with blood flow restriction and conservative therapy. Participants in this group will receive conventional physiotherapy including hot pack application over the knee for 10 minutes and TENS applied medial and lateral to the knee for 10 minutes prior to exercises. Mulligan mobilization with movement will be performed using pain free sustained tibial glides during active knee flexion and extension. Closed kinetic chain quadriceps strengthening exercises will include
  • Other Open kinetic chain exercises with blood flow restriction
    Open kinetic chain exercises with blood flow restriction and conservative therapy. Participants in this group will receive conventional physiotherapy including hot pack application over the knee for 10 minutes and TENS applied medial and lateral to the knee for 10 minutes prior to exercises. Mulligan mobilization with movement will be performed using pain free sustained tibial glides during active knee flexion and extension. Open kinetic chain quadriceps strengthening exercises will include stra

Primary outcome measures

  • Numeric Pain Rating Scale (NPRS) [Time frame: [Time Frame: Pre intervention (Week 1) and Post intervention (Week 4)]]
Secondary outcome measures (5)
  • Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) [Time frame: [Time Frame: Pre intervention (Week 1) and Post intervention (Week 4)]]
  • Knee Range of Motion (Flexion) [Time frame: [Time Frame: Pre intervention (Week 1) and Post intervention (Week 4)]]
  • Knee Range of Motion (Extension) [Time frame: [Time Frame: Pre intervention (Week 1) and Post intervention (Week 4)]]
  • Knee Muscle Strength [Time frame: [Time Frame: Pre intervention (Week 1) and Post intervention (Week 4)]]
  • 30 Second Chair Stand Test [Time frame: [Time Frame: Pre intervention (Week 1) and Post intervention (Week 4)]]

Eligibility criteria

Inclusion criteria

  • Radiologic confirmation of KOA demonstrating Kellgren-Lawrence grade 1 or 2.
  • Exhibited symptoms of unilateral KOA.
  • Not taking any medications for KOA or receiving other treatments (including physiotherapy).
  • Willing to participate without any neurological symptoms were the main objects of study.

Exclusion criteria

  • A history of knee surgery or scheduled surgery.
  • Kellgren-Lawrence grade 3 or 4.
  • Systolic blood pressure over 160 mm Hg or under 100 mm Hg.
  • Use of nonsteroidal anti-inflammatory drugs in the past 3 months.
  • Any known vascular disease or any diagnosed blood pathology.
  • Concomitant symptomatic hip or ankle pathology that could influence knee pain or function.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

Pakistan · 2 centers
  • Medistic Medical and Dental Center — Rawalpindi
  • Pakistan Railway General Hospital — Rawalpindi

Identifiers

NCT: NCT07426549 · RCRAHS-ISB/REC/MS-PT/02420

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗