Gait, Physical Activity, and Sleep in Parkinson's Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Parkinson Disease. Basic parameters: 40 years — 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Relationship Between Balance and Gait Impairments, Physical Activity Level, and Sleep Quality in Parkinson's Disease
Overview
This study aims to investigate the relationship between balance and gait impairments, physical activity levels, and sleep status in individuals with Parkinson's disease (PD). Both motor and non-motor symptoms of PD significantly affect quality of life, yet these dimensions are often evaluated separately. By examining gait, balance, physical activity, and sleep parameters together and comparing patients with healthy individuals of similar age, the study seeks to clarify how these variables interact and whether observed impairments are disease-specific or related to natural aging. The findings are expected to contribute to a more comprehensive understanding of PD and support the development of more effective management strategies.
Detailed description
This study will be conducted between January 2026 and May 2026 and will include 34 participants aged 45-70 years: 17 individuals diagnosed with Parkinson's disease and 17 age-matched healthy individuals without neurodegenerative disease. Participants will be recruited from Biruni University Hospital and Biruni University. Gait analysis will be performed using Kinovea software by recording a 3-meter walk in the sagittal plane, allowing evaluation of parameters such as step length and arm swing. Physical activity will be assessed using a 2-Minute Walk Test monitored with a pulse oximeter to measure oxygen saturation and functional exercise capacity, as well as daily step counts recorded over one week using a wearable smart band (Honor Choice Band). Balance will be evaluated using the Mini-BESTest. Sleep status will be assessed objectively through the smart band, which records deep sleep, light sleep, REM sleep, and wakefulness, and subjectively using the Pittsburgh Sleep Quality Index. Participants will install the Wear Sync application on their smartphones to enable synchronization and collection of wearable device data.
Primary outcome measures
- Mini Balance Evaluation Systems Test (Mini-BESTest) Score [Time frame: Baseline (single assessment during study participation)]
Secondary outcome measures (5)
- Kinovea-Based Gait Parameters (Step Length and Stride Length) [Time frame: Baseline (single assessment during study participation)]
- 2-Minute Walk Test (2MWT) Distance [Time frame: Baseline (single assessment during study participation)]
- Daily Step Count (Wearable-Recorded Physical Activity) [Time frame: 7 days (during one-week monitoring period)]
- Pittsburgh Sleep Quality Index (PSQI) Total Score [Time frame: Baseline (single assessment during study participation)]
- Wearable-Derived Sleep Parameters (Sleep Stages and Wake Time) [Time frame: 7 days (during one-week monitoring period)]
Eligibility criteria
Inclusion criteria
For Patients with Parkinson's Disease:
A confirmed diagnosis of Parkinson's disease according to the United Kingdom (UK) Brain Bank Criteria and classified as Hoehn and Yahr stages 1-3
Ability to walk independently on a flat surface without assistive devices (Functional Ambulation Scale ≥3)
Stable medication regimen during the past month
Being in the "on" phase of medication
For Healthy Individuals:
No diagnosis of neurological and/or neurodegenerative disease
Exclusion criteria
(For both Parkinson's patients and healthy individuals)
Severe hearing or visual impairments
Presence of other neurological, cardiovascular, or orthopedic conditions that may affect walking ability
Any additional neurological disorder (e.g., dementia, cerebrovascular disease)
Education level less than 5 years
Vascular pathologies affecting the lower extremities
Lack of smartphone use
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
Turkey (Türkiye) · 1 center
- Biruni University Hospital — Istanbul
Publications
- Bene R, Antic S, Budisic M, Lisak M, Trkanjec Z, Demarin V, Podobnik-Sarkanji S. Parkinson's disease. Acta Clin Croat. 2009 Sep;48(3):377-80. PMID 20055267
- Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):368-76. doi: 10.1136/jnnp.2007.131045. PMID 18344392
- Kalia LV, Lang AE. Parkinson's disease. Lancet. 2015 Aug 29;386(9996):896-912. doi: 10.1016/S0140-6736(14)61393-3. Epub 2015 Apr 19. PMID 25904081
Identifiers
NCT: NCT07424924 · BiruniUniv.