The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older Adults
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Preoperative physical activity level.
- Who it may be relevant to
- Registry conditions: Post Operative Delirium. Basic parameters: from 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Association of the Exercise-Irisin-EEG Cascade With Intrinsic Brain Vulnerability and Its Impact on Postoperative Delirium in Elderly Patients: A Prospective Cohort Study
Overview
The goal of this observational study is to learn how exercise-induced irisin protects the brain. It also explores irisin's effect on postoperative delirium (POD) in older adults. The main questions it aims to answer are: Does daily activity link to POD? Does irisin play a mediating role in this process? Researchers will enroll active and inactive adults aged 65 and older. All will have surgery under spinal anesthesia. The researchers will measure irisin levels in spinal fluid. They will track POD and other complications for five days after surgery.
Interventions
- Behavioral Preoperative physical activity level
Before the surgery, the activity levels of the participants over the past week were assessed using the Physical Activity Scale for the Elderly (PASE).
Primary outcome measures
- Postoperative Delirium [Time frame: five days after surgery]
Eligibility criteria
Inclusion criteria
- Aged ≥ 65 years;
- Classified as ASA physical status I to III;
- Scheduled for non-cardiovascular surgery under spinal anesthesia or combined spinal-epidural anesthesia;
- Expected surgical duration of at least 2 hours;
- Voluntarily provide written informed consent and agree to participate in this study.
Exclusion criteria
- Significant change in exercise status within the past 7 days due to injury or other reasons;
- Contraindications to neuraxial anesthesia;
- Unable to assess cognitive function or Montreal Cognitive Assessment (MoCA) score < 23;
- Preoperative diagnosis of delirium;
- History of traumatic brain injury or neurosurgery;
- Long-term opioid use or history of alcohol abuse;
- Planned surgery cancelled or changed (including intraoperative events that significantly alter the procedure or duration);
- Change in anesthesia method.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07424170 · 2026PHB056-001