Feasibility of Modulating Cognitive Control in OCD
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: continuous theta-burst transcranial magnetic stimulation (cTBS).
- Who it may be relevant to
- Registry conditions: Obsessive-Compulsive Disorder (OCD). Basic parameters: 18 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Evaluating Frontal Pole as a Window to Modulation of Cognitive Control in OCD
Overview
This study tests out procedures to look at whether a type of brain stimulation called transcranial magnetic stimulation impacts flexible shifts in behavior in obsessive-compulsive disorder (OCD). This study examines whether study procedures are feasible and acceptable to people participating in the study, but does not determine whether this type of brain stimulation causes changes.
Interventions
- Device continuous theta-burst transcranial magnetic stimulation (cTBS)
3 consecutive daily sessions of cTBS
Primary outcome measures
- Rate of enrollment [Time frame: At study enrollment]
Secondary outcome measures (2)
- Rates of visit completion [Time frame: From enrollment to date of post-TMS study visit (approximately 1 week)]
- Peak cTBS intensity tolerated [Time frame: From enrollment to end of TMS sessions (approximately 1 week)]
Eligibility criteria
Inclusion criteria
- Current primary DSM-5 OCD diagnosis and current Y-BOCS total score of ≥16 (OCD group, only) or no current diagnosis of an emotional disorder, and no known history of OCD, PTSD, anxiety disorder(s), or recurrent major depressive disorder (Healthy participant group, only)
- 18-60 years of age
- ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide informed consent
- psychotherapy and/or psychiatric medication use remain stable for 6 weeks prior to study entry
Exclusion criteria
- Presence of current psychiatric diagnosis (healthy control group, only)
- active substance use disorder
- history of mania or hypomania, or lifetime presence of significant psychotic symptoms
- active suicidal or homicidal ideation
- use of medications known to reduce seizure threshold (e.g., stimulants)
- organic brain disease or injury representing a contraindication to TMS
- any health problems that would interfere with safe and/or practical study participation, including contraindications to TMS (e.g., seizure disorder, presence of metal hardware that would come in close contact with the discharging coil)
- current pregnancy or planning to become pregnant during the study period
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Other
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07419009 · STUDY02003117