Minimum Effective Exercise Intensity in Sedentary Individuals
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Exercise.
- Who it may be relevant to
- Registry conditions: Sedentary Individuals Not Participating in Regular Exercise Training/Physical Activity. Basic parameters: 30 years — 55 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Finland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Minimum Effective Exercise Intensity for Improving Cardiorespiratory Fitness and Cardiometabolic Health in Sedentary Individuals
Overview
The aim of this randomized controlled intervention study is to examine the minimum exercise intensity that has an effect on cardiorespiratory fitness and/or cardiometabolic risk factors in sedentary adults. In addition, the study seeks to examine which background factors explain individual differences in exercise responses.
Detailed description
The study consists of a 2-week baseline period followed by two 6-week intervention periods. The study will compare changes in the predefined outcome variables between the exercise intervention groups and the control group that does not perform any exercise training. In addition to intensity prescribed relative to oxygen uptake reserve, exercise intensity will be retrospectively analyzed in relation to the first ventilatory threshold in order to examine the lowest effective intensity using this method as well. Among background factors, possible modifiers assumed on the basis of previous literature, will be analyzed to assess their contribution to inter-individual differences in the outcome responses. Potential main contributors are considered to be sex, the basal value of the outcome, nutritional habits, physical activity and stationary behavior outside the prescribed training, and non-invasive indicators of stress.
Interventions
- Other Exercise
6 weeks of 3 x 30 min/week supervised cycle ergometer training and 6 weeks of 3 x 40-50 min/week supervised cycle ergometer training
Primary outcome measures
- Maximal oxygen consumption [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
- Ventilatory thresholds [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
Secondary outcome measures (12)
- Pmax [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
- Concentration of LDL cholesterol [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
- Concentration of HDL cholesterol [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
- Concentration of total cholesterol [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
- Concentration of triglycerides [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
- Concentration of blood glucose [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
- Concentration of insulin [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
- HOMA-IR [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
- HbA1c [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
- Blood pressure [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
- Resting heart rate [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
- Resting heart rate variability [Time frame: Pre (week 0), mid (after 6 weeks), post (after 12 weeks)]
Eligibility criteria
Inclusion criteria
- 30-50-year old males and females
- Sedentary, not participating in regular exercise training/physical activity
Exclusion criteria
- Cardiovascular symptoms/diseases
- Musculoskeletal symptoms/diseases
- Metabolic diseases
- Resting blood pressure > 160/100 mmHg
- Body mass index ≥ 35
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Basic science
Study locations
Finland · 2 centers
- UKK institute for Health Promotion Research — Tampere
- Paavo Nurmi Centre — Turku
Identifiers
NCT: NCT07418619 · MINI26