CGF Partial Pulpotomy Versus Endodontic Treatment
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Other treatment, Other treatment.
- Who it may be relevant to
- Registry conditions: Irreversible Pulpitis. Basic parameters: 11 years — 17 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Partial Pulpotomy Usung CGF Versus Endodontic Treatment in Treating Irreversibly Inflamed Mature Peramnent Molars
Overview
partial pulpotomy of mature molars with irrevesible pulptits using CGF in adolescents
Detailed description
partial pulpotomy of mature molars with irrevesible pulptits using CGF in adolescents form 12-17 years old versus endodontic treatment with a 2 years follow up
Interventions
- Procedure Other treatment
partial pulpotomy using CGF in irreversibly inflamed mature molars in adolescents - Procedure Other treatment
endodontic treatment using guttapercha in irreversibly inflamed molars in adolescents
Primary outcome measures
- The primary outcome was to compare the cumulative pain responses using modified VAS scores. [Time frame: one week]
- Pulpal blood biomarkers [Time frame: one week]
Secondary outcome measures (3)
- clinical follow up [Time frame: one week]
- clinical follow up [Time frame: one week]
- Radiographic follow up [Time frame: 2 years]
Eligibility criteria
Inclusion criteria
- Patient-based criteria: Class ASA I or II cooperative adolescents of 11 - 17 years. Based on a 10 cm modified visual analog scale (VAS), only patients who reported a preoperative pain intensity score of ≥ 7, indicative of severe pain were included.
Tooth-based criteria: Presence of occlusal extremely deep carious lesion with pulp exposure of mandibular first permanent molars with closed apices (i.e. class V according to Cvek's stages of root development) with sound contralateral molars to provide a reference for biomarker quantification and pulp sensibility tests. Only teeth diagnosed with symptomatic irreversible pulpitis (SIP) were included. To validate the diagnosis of SIP, the teeth with the teeth diagnosed with symptomatic irreversible pulpitis (SIP) were included. To validate the diagnosis of SIP, the teeth with the following criteria were exclusively included:
- History of sharp, spontaneous, and lingering pain that was precipitated by thermal provocation and lasted mostly for ≥ 30 seconds.
- Early prolonged, intense, and lingering response to cold thermal stimulus and positive response electric pulp test (EPT) at low thresholds.
- Normal color and appearance of the tooth surrounding gingival tissues with no evidence of gingival inflammation, swelling, abnormal tooth mobility, or sinus tract or fistula formation upon visual and palpation inspections.
- Preoperative periapical radiograph with evidence of caries penetrating the entire thickness of the dentin with no isolating radiopaque zone separating the lesion from the pulp indicating extremely deep caries.
- Normal radiographic findings in terms of intact periodontal membrane space
Exclusion criteria
Patient-based criteria: Patients with a positive history of the following conditions were excluded:
- Emotional or behavioral problems and those receiving antidepressant drugs.
- Under treatment with antibacterial or anti-inflammatory medicaments for the last four weeks (Akbal Dincer et al., 2020).
- Localized or generalized gingivitis and/or periodontitis with loss of epithelial attachment ≥ 3mm upon probing.
- Poor oral hygiene with dense accumulation of calculus or dental plaque.
- Systemic conditions such as diabetes, bleeding, immunological disorders.
Tooth-based criteria:
- Teeth with abnormal structure or developmental anomalies.
- Persistent hemorrhage from the root canal orifices lasting longer than 10 minutes.
- Loss of coronal structure beyond restorability
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Pediatric and Community Dentistry Department , Faculty of Dentistry , Minia University — Minya
Publications
- Nawal RR, Yadav S, Duncan HF, Talwar S, Kaushik A, Singh VK, Koner BC. Discriminatory performance of the pulpal inflammatory biomarkers; Interleukin-8 and TNF-alpha in patients with symptoms indicative of reversible and irreversible pulpitis: A diagnostic accuracy study. Int Endod J. 2024 Sep;57(9):1200-1211. doi: 10.1111/iej.14078. Epub 2024 May 4. PMID 38703070
- Sabeti MA, Nikghalb K, Pakzad R, Fouad AF. The Relationship Between Pulpal Diagnostic Conditions and Potential Inflammatory Biomarkers. Int Endod J. 2026 Jan;59(1):23-37. doi: 10.1111/iej.70030. Epub 2025 Sep 9. PMID 40923157
- Karrar RN, Cushley S, Duncan HF, Lundy FT, Abushouk SA, Clarke M, El-Karim IA. Molecular biomarkers for objective assessment of symptomatic pulpitis: A systematic review and meta-analysis. Int Endod J. 2023 Oct;56(10):1160-1177. doi: 10.1111/iej.13950. Epub 2023 Jul 17. PMID 37392154
- Uesrichai N, Nirunsittirat A, Chuveera P, Srisuwan T, Sastraruji T, Chompu-Inwai P. Partial pulpotomy with two bioactive cements in permanent teeth of 6- to 18-year-old patients with signs and symptoms indicative of irreversible pulpitis: a noninferiority randomized controlled trial. Int Endod J. 2019 Jun;52(6):749-759. doi: 10.1111/iej.13071. Epub 2019 Jan 30. PMID 30638262
Identifiers
NCT: NCT07417098 · MiniaU pedo dept