Variability of Microwave Ablation Volume Based on Clinical, Radiological, Biological, and Tissue Factors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Liver Neoplasm. Basic parameters: 18 years — 100 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Variability of Microwave Ablation Volume Based on Clinical, Radiological, Biological, and Tissue Factors : a Retrospective Study
Overview
Microwave ablation is a minimally invasive technique whose planning relies on manufacturer tables derived from ex vivo models that do not account for patient or tumor-specific factors. In clinical practice, the actual ablation volume often differs from the planned volume due to liver characteristics, vascular proximity, and tumor biology. This study aims to assess the variability between ablation small axis during percutaneous microwave ablation of liver lesions. The influence of patient-related (fibrosis, steatosis, portal flow) and tumor-related factors (location, histology, prior treatment) will be evaluated. Small axis and volume will be compared with volumes measured on immediate post-procedural CT and on CT/MRI at 6-12 weeks, accounting for expected tissue shrinkage.
Primary outcome measures
- Small final ablation axis measured on the post-procedure imaging modality considered to be the most reliable. [Time frame: 12 weeks]
Eligibility criteria
Inclusion criteria
- Adult patients
- Treated with percutaneous hepatic microwave ablation under CT or ultrasound guidance
- Adult treated for one or more liver lesions
- Patients with available follow-up imaging
Exclusion criteria
- Two treatment cycles on the same lesion during the same session.
- Reoperation on the same lesion.
- Planned volume not available (no manufacturer data, not specified in the surgical report).
- No control imaging injected between 1 and 4 months post-procedure.
- Final ablation volume not measurable (e.g., artifacts, no injection on MRI).
- No definitive diagnosis of the nature of the tumor on imaging and no histology available.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- CHRU Nancy — Vandœuvre-lès-Nancy
Identifiers
NCT: NCT07413640 · 2025PI_230