Recruiting NCT07409207
Neurophysiology of Reward Signaling in Parkinson's Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Neurophysiology recordings, Neural stimulation.
- Who it may be relevant to
- Registry conditions: Parkinson Disease. Basic parameters: from 40 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
Interventions
- Other Neurophysiology recordings
Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated - Other Neural stimulation
Neural stimulation will be delivered during a gambling task and its impact on task performance quantified
Primary outcome measures
- Changes in caudate DLPFC beta coherence [Time frame: Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours]
- Changes in gambling task performance with neural stimulation [Time frame: Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours]
Secondary outcome measures (1)
- Change in beta power with neural stimulation [Time frame: Baseline to end of deep brain stimulation (DBS) surgery, approximately 3-4 hours]
Eligibility criteria
Inclusion criteria
- Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
- Planned clinical electrode trajectory that contacts caudate
- Age greater than or equal to 40
- Diagnosis of Parkinson's disease or other movement disorder
- Able to participate in intraoperative testing
- English speaking
Exclusion criteria
- Age less than 40
- Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 1 center
- Vanderbilt University Medical Center — Nashville
Identifiers
NCT: NCT07409207 · K08NS140767 · 201868