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Recruiting NCT07399093

Preoperative Evaluation of IVC Collapsibility Index and Caval Aorta Index After Induction of General Anesthesia

— Observational Inferior Vena Cava Collapsibility Index Caval Aorta Index Induction

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Inferior vena cava collapsibility index, Caval Aorta Index.
Who it may be relevant to
Registry conditions: Inferior Vena Cava, Collapsibility Index, Caval Aorta Index, Induction. Basic parameters: 18 years — 40 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Egypt
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Preoperative Evaluation of IVC Collapsibility Index and Caval Aorta Index for Prediction of Hypotension After Induction of General Anesthesia in Patients Undergoing Craniotomy Surgeries

Overview

This study aims to assess the accuracy, repeatability, and reproducibility of preoperative evaluation of Inferior Vena Cava (IVC) collapsibility index and caval aorta index for prediction of hypotension after induction of general anesthesia.

Detailed description

Post- anesthesia hypotension is of common occurrence, and it hampers tissue perfusion. The magnitude of hypotension is determined by the preoperative volume status, which varies depending on American Society of Anesthesiologists (ASA) physical status, preoperative comorbidities, preoperative medications, and fasting.

General anesthesia causes significant alterations in hemodynamics, as both inhalational and intravenous anesthetics cause bradycardia, decrease in systemic vascular resistance and vasodilatation, and decrease in myocardial contractility, cardiac output and stroke volume, with the absence of surgical stimulus, making induction of anesthesia is the most crucial period at which hypotension occurs.

Due to different definitions of hypotension and diverse patient populations, the effect of volume preload on prevention of hypotension is still controversial. Many recommendations to identified sonographic determination of inferior vena cava (IVC) collapsibility index (IVCCI) as non-invasive, and easy technique for evaluating volume status. Recent guidelines from the American Society of Echocardiography support the general use of IVCCI in assessing volume status.

Interventions

  • Other Inferior vena cava collapsibility index
    Inferior vena cava (IVC) collapsibility index (IVCCI) will be measured. The IVCCI is calculated using the following formula: IVCCI = (maximum IVC diameter - minimum IVC diameter) / maximum IVC diameter \* 100
  • Other Caval Aorta Index
    The Inferior vena cava (IVC): Ao index will be derived by taking the ratio of the maximum IVC diameter during expiration and the maximal abdominal aortic diameter during systole. \- The caval aorta index (IVC/Ao) is calculated using the following formula: IVC/Ao index = IVC diameter / aortic diameter.

Primary outcome measures

  • Sensitivity of ultrasound guided Aorto-Caval index (IVC-AO) [Time frame: 15 minutes post-induction of general anesthesia.]
Secondary outcome measures (3)
  • Specificity of ultrasound guided Aorto-Caval index (IVC-AO) [Time frame: 15 minutes post-induction of general anesthesia.]
  • Sensitivity of inferior vena cava (IVC) collapsibility index [Time frame: 15 minutes post-induction of general anesthesia.]
  • Specificity of inferior vena cava (IVC) collapsibility index [Time frame: 15 minutes post-induction of general anesthesia.]

Eligibility criteria

Inclusion criteria

  • Age from 18 to 40 years.
  • Both sexes.
  • Body Mass Index< 40 kg/m².
  • American Society of Anesthesiologists (ASA) physical status I, II.
  • Fasted according to the ASA guidelines: 2 hours for clear fluids, 6 hours after light meal, 8 hours after a full meal with high calorie or fat content.
  • Scheduled for elective craniotomy surgeries before induction of general anesthesia.

Exclusion criteria

  • Current or recent pregnancy (within 3 months).
  • Pre-existing cardiac disease or hypertension.
  • On medications affecting blood pressure \[Beta-blockers (BBs) and calcium channel blockers (CCBs)\] .
  • Refusing to undergo the study.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

Egypt · 1 center
  • Ain Shams University Hospitals — Cairo

Identifiers

NCT: NCT07399093 · FMASU MD08/2024

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗