Metabolic Characteristics and Prognostic Model of Acute Coronary Syndrome Complicated With Obstructive Sleep Apnea
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Biological Sample Collection.
- Who it may be relevant to
- Registry conditions: Sleep Disordered Breathing (SDB). Basic parameters: 18 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Metabolic Characteristics Analysis and Precise Prognostic Model Establishment for Patients With Acute Coronary Syndrome Complicated With Obstructive Sleep Apnea
Overview
Obstructive sleep apnea (OSA) significantly increases the risk of cardiovascular events in patients with acute coronary syndrome (ACS), yet the underlying metabolic mechanisms remain unclear. This study aims to analyze the metabolic characteristics of ACS patients with OSA using metabolomics based on a prospective cohort. The study intends to construct an artificial intelligence-based risk stratification model to improve prognosis prediction and facilitate precision medicine for this population.
Interventions
- Other Biological Sample Collection
Collection of blood, urine, and stool samples for metabolomics analysis.
Primary outcome measures
- Incidence of Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) [Time frame: 12 Months]
Eligibility criteria
Inclusion criteria
- Age 18-85 years.
- Diagnosed with ACS, including ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, and unstable angina.
- Willing to participate and sign the informed consent form.
Exclusion criteria
- Cardiogenic shock or cardiac arrest.
- Central sleep apnea or other types of sleep disordered breathing.
- Previous or current treatment with continuous positive airway pressure.
- Inability to complete polysomnography or invalid data.
- Malignancy or life expectancy < 1 year.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07398430 · 2025BJYYEC-KY309-02