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Recruiting NCT07395778

Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis

No phase Interventional Walled Off Pancreatic Necrosis Acute Pancreatitis (AP) Endoscopic Ultrasound-Guided Drainage

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: endoscopic ultrasonography guided cystogastrostomy.
Who it may be relevant to
Registry conditions: Walled Off Pancreatic Necrosis, Acute Pancreatitis (AP), Endoscopic Ultrasound-Guided Drainage. Basic parameters: 18 years — 75 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
India
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis: A Randomized Controlled Pilot Study

Overview

The goal of this randomized control trial is to assess whether nasojejunal feed is better than oral nutrition in patients who are undergoing endoscopic cystogastrostomy of walled off necrosis following acute pancreatitis. It will also try to answer, the incidence of infections and feed tolerance. The main question it tries to answer is 1. whether nasojejunl feed is better than oral feed in patients undergoing endoscopic cystogastrostomy in walled off necrosis following acute pancreatitis 2. How much infections they develop, whether they are able to tolerate the feed, weight gain and reintervention rates in each group

Interventions

  • Procedure endoscopic ultrasonography guided cystogastrostomy
    Nasojejunal tube will be placed post EUS-CG or oral diet would be started after randomization

Primary outcome measures

  • Nutritional failure [Time frame: 14 days]
Secondary outcome measures (4)
  • Infection and new onset organ failure [Time frame: 14 days]
  • Re-intervention needs [Time frame: 14 days]
  • Change in weight [Time frame: 14 days]
  • Inflammatory markers [Time frame: 14 days]

Eligibility criteria

Inclusion criteria

  • Patients of acute pancreatitis (AP) with 18-75 years of age
  • Patients with symptomatic WON requiring EUS guided transluminal drainage
  • Provision of written informed consent

Exclusion criteria

  • Patients with collection not amenable for EUS guided drainage (distance of WON >1 cm from the gastrointestinal lumen)
  • Known malignancy or immunocompromised state
  • Previous upper gastrointestinal(GI) surgery interfering with absorption
  • Active GI bleeding
  • GI obstruction, ileus or persistent vomiting
  • Patients moribund to undergo endoscopic procedure (Glasgow coma scale <8 or patients on ventilatory support)
  • Patients with irreversible coagulopathy like platelets <50,000/mm3 and/or INR>1.5
  • Pregnant or lactating female

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Supportive care

Study locations

India · 1 center
  • Post Graduate Institute of Medical Education and Research (PGIMER) — Chandigarh

Identifiers

NCT: NCT07395778 · IEC-INT/2025/DM-3119

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗