Surgical Handling of Fertility-preserving Treatments for Cervical Adenocarcinomas
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Cervical Adenosarcoma. Basic parameters: from 18 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Despite a growing body of literature on the subject, there is still uncertainty regarding direct comparisons between different conservative surgical techniques for cervical adenocarcinomas. In particular, it remains unclear whether fertility-sparing surgery for cervical adenocarcinomas - characterized by skip lesions - can ensure optimal disease control while achieving adequate obstetric outcomes. For this reason, a systematic review and meta-analysis of the literature, along with an analysis of our center's data, is warranted. This approach will allow a critical, comparative evaluation of the efficacy of the different techniques (conization, simple trachelectomy, and radical trachelectomy) and the identification of prognostic factors to guide therapeutic choice.
Primary outcome measures
- Recurrence rate [Time frame: 5 years]
- Disease free survival [Time frame: 5 years]
- Overall survival [Time frame: 5 years]
Secondary outcome measures (2)
- pregnancy rate [Time frame: 5 years]
- live birth rate [Time frame: 5 years]
Eligibility criteria
Inclusion criteria
- Adult women of reproductive age with a diagnosis of cervical adenocarcinoma
- Undergoing fertility-sparing surgery
- Minimum 12-month follow-up
- Signed informed consent
Exclusion criteria
- Histotypes other than cervical adenocarcinoma
- Undergoing radical surgery
- Follow-up less than 12 months
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
Italy · 1 center
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS — Roma
Identifiers
NCT: NCT07394413 · 7939