Musculoskeletal Outcomes Using Tylenol/Ibuprofen vs. Oral Steroids in New Injuries
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Methylprednisolone 4Mg Tab, Acetaminophen 500Mg Tab, Ibuprofen 200Mg Oral Tablet.
- Who it may be relevant to
- Registry conditions: Musculoskeletal Pain. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
In this pilot study, the investigators aim to compare two short-term pain relief methods administered over the course of 6 days in the setting of acute musculoskeletal (MSK) pain: 1. Methylprednisolone((Medrol)dose pack- standard taper per dose pack instructions 2. Standard of Care (SOC) which includes a combination of Acetaminophen (Tylenol)+Ibuprofen (Motrin) The investigators are interested in studying pain relief regimens for acute injury of any body part among an adult orthopaedic urgent care population.
Interventions
- Drug Methylprednisolone 4Mg Tab
Participants follow standard 6- day taper dosing schedule. - Drug Acetaminophen 500Mg Tab
Participants follow a 6- day taper dosing schedule. - Drug Ibuprofen 200Mg Oral Tablet
Participants follow a 6- day taper dosing schedule.
Primary outcome measures
- Change in Pain [Time frame: 1 week, 1 month]
Secondary outcome measures (1)
- Change in Function [Time frame: 1 week, 1 month]
Eligibility criteria
Inclusion criteria
- Adults 18+
- Able to answer survey questions in English
- MSK pain > 3 on the VAS scale in any body part
- Invited to participate by and enrolling clinician
Exclusion criteria
- > 2 weeks from pain onset
- Fractures
- Active infections
- Anaphylactic reaction to either medication (Oral Steroids, Ibuprofen, and/or Acetaminophen)
- Currently taking anti-platelet agents (aspirin </= 100/mg a day, clopidogrel, etc.)
- Chronic Kidney Disease Stage 3 or worse
- Uncontrolled diabetes (A1C above 9)
- Currently taking oral anti-coagulants
- History of bleeding ulcer
- Cirrhosis
- Taking daily prednisone
- Chronic pain syndrome
- Chronic pain medication (gabapentin, Lyrica, narcotics, etc.)
- Pregnant Patients
- Worker's Compensation Patients
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Sequential
- Masking
- Single blind
- Primary purpose
- Other
Study locations
United States · 1 center
- UBMD Orthopaedics and Sports Medicine (716 Health) — Buffalo
Identifiers
NCT: NCT07393503 · STUDY00009423