Identifying Risk Factors and Predicting Future Health Outcomes for Korean Patients With Heart and Blood Vessel Diseases: A Long-term Follow-up Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Standard Medical Therapy, Revascularization Procedures, Lifestyle Modification.
- Who it may be relevant to
- Registry conditions: Cardiovascular Diseases (CVD), Cerebro Vascular Disease. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- South Korea
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
PRIME (Precision Registry for Integrated Cardio-cerebrovascular Medicine & Evidence)
Overview
This study aims to establish a comprehensive, long-term clinical registry infrastructure for heart and brain vascular diseases (cardiovascular diseases and stroke) at Samsung Medical Center. In South Korea, these diseases are a leading cause of death, with a rapidly increasing burden due to an aging population and changing lifestyles. Despite this, there is a lack of large-scale, systematic data specifically focused on the long-term clinical course and unique characteristics of Korean patients. The central hypothesis of this study is that the establishment of a standardized registry infrastructure-integrating both retrospective (historical) and prospective (future) data collection-will provide a more accurate and comprehensive understanding of the natural history and risk factors of heart and brain vascular diseases in the Korean population than currently available fragmented data. By combining existing medical records with ongoing patient follow-up, this infrastructure will serve as a critical scientific platform for developing personalized prevention and precision medicine strategies. By building this organized data collection system, the study will: Construct a robust infrastructure to collect uniform, high-quality clinical data, encompassing both past medical history (retrospective) and future clinical progress (prospective) from a large population of Korean patients. Monitor long-term health outcomes and the progression of diseases by tracking patients over many years. Analyze the interaction between various risk factors and patient outcomes to identify population-specific patterns. Create a scalable platform that can integrate advanced technologies, such as multi-omics and digital health tools, for future research. Ultimately, this integrated registry infrastructure is expected to provide the essential scientific evidence needed to optimize clinical guidelines and improve the long-term quality of life for patients with heart and brain vascular diseases in Korea.
Interventions
- Drug Standard Medical Therapy
Routine pharmacological treatments including antiplatelets, antihypertensives - Procedure Revascularization Procedures
Surgical or interventional procedures such as PCI (Percutaneous Coronary Intervention) or stent thrombectomy for stroke. - Behavioral Lifestyle Modification
Habitual factors including smoking cessation, physical activity, and dietary habits monitored during the follow-up.
Primary outcome measures
- Incidence of Major Adverse Cardio-Cerebrovascular Events (MACCE) [Time frame: Up to 20 years (from the date of enrollment until the end of the follow-up period)]
Eligibility criteria
Inclusion criteria
A patient who visited Samsung Medical Center due to cardiovascular and cerebrovascular disease.
Exclusion criteria
A patient deemed unable to participate in the study based on the judgment of the medical staff.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
South Korea · 1 center
- Samsung Medical Center — Seoul
Identifiers
NCT: NCT07393412 · SMC IRB 2025-12-061