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Recruiting NCT07392411

Study on Artificial Intelligence-Based Facial and Speech-Related Patterns in Parkinson's Disease and Their Digital Biomarkers

— Observational Parkinson's Disease Progressive Supranuclear Palsy(PSP) Multiple System Atrophy Healthy Control

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: video recording.
Who it may be relevant to
Registry conditions: Parkinson's Disease, Progressive Supranuclear Palsy(PSP), Multiple System Atrophy, Healthy Control. Basic parameters: 15 years — 75 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

This research employs AI to analyze facial expressions and speech patterns, aiming to develop new digital tools for diagnosing and differentiating Parkinson's disease and similar disorders.

Interventions

  • Other video recording
    The patient's facial expressions and speech characteristics were recorded via video for assessment purposes.

Primary outcome measures

  • Diagnostic Accuracy of the AI Model in Assessing [ Disease/Condition ] Severity [Time frame: Baseline]

Eligibility criteria

Inclusion criteria

  • Inclusion Criteria for Parkinson's Disease (PD) Group: (1) Diagnostic Criteria: Meet the diagnostic criteria for Parkinson's disease established by the Movement Disorder Society (MDS) in 2015. (2) Age Range: 18-75 years old. (3) Disease Severity: Early-stage PD: Hoehn-Yahr score ≤ 2.5 points. Mid-to-late-stage PD: Hoehn-Yahr score 2.5-5 points. (4) Consent for Data Collection: Willing to undergo facial expression video and speech audio recording. (5) Informed Consent: Signed informed consent form.
  • Inclusion Criteria for Parkinson's Plus Syndromes (MSA-P, PSP) Group: (1) Age Range: 18-75 years old. (2) Diagnostic Criteria: MSA patients must meet the diagnostic criteria established by the \[Chinese Expert Consensus on the Diagnosis of Multiple System Atrophy, 2017\]. PSP patients must meet the diagnostic criteria established by the \[Chinese Clinical Diagnostic Criteria for Progressive Supranuclear Palsy, 2016 Edition\]. (3) Consent for Data Collection: Willing to undergo facial expression video and speech audio recording. (4) Informed Consent: Signed informed consent form.

Exclusion criteria

  • History of cerebrovascular disease, head trauma, hydrocephalus, brain tumors, or intracranial surgery.
  • Presence of metal implants, cardiac pacemakers, or other metallic foreign bodies (applies to PD patients).
  • Severe dyskinesia in PD patients that would compromise cooperation with video/audio recording.
  • Mini-Mental State Examination (MMSE) score ≤ 24 points.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

China · 1 center
  • 首都医科大学附属北京天坛医院 — Beijing

Identifiers

NCT: NCT07392411 · 7232048

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗