Achilles Tendon Rupture Patient Outcomes at 12 Months

This study is a cross-sectional observational investigation designed to evaluate objective and patient-reported recovery outcomes following non-surgical management of Achilles tendon rupture using the Swansea Morriston Achilles Rupture Treatment (SMART) rehabilitation protocol. The study is conducted within a National Health Service (NHS) setting at Liverpool University Hospitals NHS Foundation Trust.

Participants will be identified from an established clinical database of patients who have sustained an Achilles tendon rupture and completed non-operative rehabilitation. Eligible individuals will be invited to attend a single assessment session at 12-15 months post-injury. This time point has been selected to reflect longer-term recovery, as previous literature has predominantly focused on early and mid-term outcomes.

Study Procedures and Data Collection During the study visit, participants will undergo a comprehensive assessment including objective, clinical, and patient-reported measures. Isokinetic dynamometry will be used to quantify plantarflexor muscle performance under controlled conditions. Testing will be standardised, including participant positioning, joint alignment, range of motion, and angular velocities. Outcome variables will include peak torque and torque relative to body mass, allowing both within-participant and between-participant comparisons.

Achilles tendon structural characteristics will be assessed indirectly using the Achilles Tendon Resting Angle (ATRA), a clinically applicable proxy for tendon elongation. Measurements will be taken bilaterally using a standardised protocol with repeated trials to improve reliability, and side-to-side differences will be calculated.

Participants will also complete validated patient-reported outcome measures to capture functional status and general health. Additional contextual variables, including return-to-sport status and pre-injury Achilles symptoms, will be recorded to enable exploratory subgroup analyses.

Data Management and Quality Assurance All study data will be recorded using a structured case report form and stored within a secure, NHS-hosted electronic data capture system (REDCap). Data will be pseudonymised at the point of entry, with each participant assigned a unique study identifier. Identifiable information will be stored separately from research data and accessible only to authorised study personnel.

Data quality will be maintained through predefined validation rules within the data capture system, including range checks and logical consistency checks across related variables. Regular data monitoring will be conducted by the research team to ensure completeness and accuracy. Source data verification may be undertaken by comparing selected data fields against original clinical records where necessary.

A data dictionary will be maintained to define all study variables, including measurement units, coding structures, and allowable ranges. Standard Operating Procedures (SOPs) will guide all aspects of study conduct, including participant identification, data collection, data entry, and data storage, ensuring consistency across sites.

Sample Size Justification The sample size has been determined based on statistical considerations for detecting meaningful differences in strength between limbs as well as associations between objective and patient-reported outcomes. Allowance has been made for incomplete data to ensure adequate statistical power for primary analyses.

Statistical Analysis Plan Data analysis will be conducted using established statistical software. Continuous variables will be assessed for normality and summarised using appropriate descriptive statistics. Associations between variables will be explored using correlation analyses, with parametric or non-parametric methods applied as appropriate. Comparative analyses may be performed for exploratory subgroup comparisons (e.g., return to sport categories or presence of pre-injury symptoms).

All analyses will be interpreted within the context of an observational study design, and findings will be considered hypothesis-generating.

Handling of Missing Data Missing data will be assessed to determine patterns and potential sources (e.g., non-response, incomplete testing). Where feasible, analyses will be conducted using available data without imputation. The extent and impact of missing data will be reported transparently, and sensitivity analyses may be undertaken if appropriate.

Study Oversight and Governance The study is conducted in accordance with Good Clinical Practice (GCP), the Declaration of Helsinki, and NHS research governance frameworks. All study personnel are trained in study procedures to ensure standardisation. Data handling complies with the UK General Data Protection Regulation (GDPR) and Data Protection Act 2018.

• Correlation between isokinetic strength and ATRS [Time frame: 12-15 months post injury]
• Health-related quality of life [Time frame: 12-15 months post injury]
• Achilles Tendon Resting Angle [Time frame: 12-15 months post injury]
• Return to sport/activity status [Time frame: 12-15 months post injury]
• Pre-injury Achilles symptoms [Time frame: 12-15 months post injury]