Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Reproductive Issues. Basic parameters: 18 years — 42 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy: a Prospective Observational Study
Overview
Hypotheses: We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates. Aims: To evaluate the relationship between serum progesterone levels on embryo transfer day and clinical pregnancy outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy (HRT). Primary outcome: To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing frozen embryo transfer with caterized Progesterone level on the day of embryo transfer Secondary outcomes: Biochemical pregnancy rate. Implantation rate. Early pregnancy loss rate. Ectopic pregnancy rate.
Primary outcome measures
- Clinical pregnancy rate (CPR) [Time frame: 6 weeks of gestation and ultrasound scanning will be performed to confirm at least one gestational sac around 1 to 3 months after FET]
Secondary outcome measures (4)
- Biochemical pregnancy rate [Time frame: Up to 12 weeks]
- Implantation rate [Time frame: Up to 12 weeks]
- Early pregnancy loss rate [Time frame: Up to 12 weeks]
- Ectopic pregnancy rate [Time frame: Up to 12 weeks]
Eligibility criteria
Inclusion criteria
- Patients undergoing FET cycles
- Infertility patients aged >18 years old and < 42 years old
- BMI < 30 kg/m2
- Transfer of at least one good-quality embryo.
Exclusion criteria
- Severe endocrine disorders (e.g., thyroid dysfunction, premature ovarian failure).
- Severe uterine factors without treatment (severe endometriosis, extensive or subendometrial fibroid, uterine adherent, endometrial polyps)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
China · 1 center
- The Chinese University of Hong Kong — Hong Kong
Identifiers
NCT: NCT07388797 · 2025.875