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Recruiting NCT07388745

ESPB vs SPSIP for Postoperative Analgesia After CABG

No phase Interventional Coronary Arterial Disease Coronary Artery Bypass Grafting (CABG) Surgery Postoperative Pain Management

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Ultrasound-guided Erector Spinae Plane Block (ESPB), Ultrasound-guided Serratus Posterior Superior Intercostal Plane Block (SPSIPB).
Who it may be relevant to
Registry conditions: Coronary Arterial Disease, Coronary Artery Bypass Grafting (CABG) Surgery, Postoperative Pain Management. Basic parameters: 45 years — 85 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

A Randomized Trial Comparing Erector Spinae Plane Block Versus Serratus Posterior Superior Intercostal Plane Block for Postoperative Analgesic Efficacy in Patients Undergoing Coronary Artery Bypass Graft Surgery

Overview

This prospective, randomized, active-controlled, double-blind, parallel-group study compares the postoperative analgesic efficacy and safety of ultrasound-guided bilateral Erector Spinae Plane Block (ESPB) versus bilateral Serratus Posterior Superior Intercostal Plane Block (SPSIPB) in adult patients (45-85 years, ASA I-III) undergoing elective coronary artery bypass graft surgery. The primary outcome is postoperative pain intensity assessed by Numeric Rating Scale (NRS) at 2, 4, 8, 16, 24, and 48 hours after surgery. Secondary outcomes include intraoperative fentanyl/remifentanil consumption, postoperative morphine consumption, patient-controlled analgesia (PCA) demand/delivery parameters (if PCA is used), need for rescue analgesics, extubation and mobilization times, peak inspiratory flow measured by incentive spirometry at predefined time points, ICU and hospital length of stay, recovery quality (QoR-15 at 0, 24, and 48 hours), mortality, and block-related adverse events.

Interventions

  • Procedure Ultrasound-guided Erector Spinae Plane Block (ESPB)
    Bilateral ultrasound-guided ESPB performed preoperatively under sedation at the T4-T5 transverse process level using 20 mL of 0.25% bupivacaine per side (total 40 mL).
  • Procedure Ultrasound-guided Serratus Posterior Superior Intercostal Plane Block (SPSIPB)
    Bilateral ultrasound-guided SPSIPB performed preoperatively under sedation at the 2nd-3rd intercostal space using 20 mL of 0.25% bupivacaine per side (total 40 mL).

Primary outcome measures

  • Postoperative pain intensity [Time frame: 2, 4, 8, 16, 24, and 48 hours after surgery]
Secondary outcome measures (3)
  • Cumulative postoperative opioid consumption [Time frame: First 24 hours after surgery]
  • Need for rescue analgesia [Time frame: Up to 48 hours after surgery]
  • Quality of Recovery (QoR-15) score [Time frame: Baseline (preoperative), postoperative 24 hours, and 48 hours after surgery]

Eligibility criteria

Inclusion criteria

  • Age 45-85 years
  • Scheduled for elective coronary artery bypass graft (CABG) surgery
  • American Society of Anesthesiologists (ASA) I-II-III
  • Patients who provide written informed consent and agree to participate in the study

Exclusion criteria

  • Emergency cases
  • ASA IV-V
  • Known allergy to local anesthetics
  • Coagulopathy (platelet count <100,000/mm³, INR >1.5, aPTT >1.5× normal)
  • Infection at the block injection site
  • Pregnancy
  • Patients who do not provide written informed consent or decline to participate after being informed

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Double blind
Primary purpose
Treatment

Study locations

Turkey (Türkiye) · 1 center
  • Kütahya Health Sciences University Hospital — Kütahya

Identifiers

NCT: NCT07388745 · KSBÜ-KVC-CABG-ESPB-SPSIPB-2026

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗