Assessment of GARP Expression in Acute and Chronic Coronary Syndrome
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Arterial blood sample.
- Who it may be relevant to
- Registry conditions: Atheroma; Heart. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Belgium
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Assessment of GARP Expression and Inflammatory Cytokines in Acute and Chronic Coronary Syndrome
Overview
The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions. The genesis of atherosclerosis is linked to both lipid accumulation and inflammation in the vascular wall of major arteries. One of the major pathways of inflammation is the TGF-beta axis which is at least partially regulated by the GARP protein. It has been investigated mostly in cancer biology but data in cardiovascular disease is lacking. Thus, the investigators aim to characterize the contribution of this protein by investigating its expression in circulating blood cells from patients with an acute or chronic coronary syndrom. The main cells expressing the GARP protein are the platelets and the T regulating cells which will be the main focus.
Interventions
- Biological Arterial blood sample
An arterial blood sample will be obtained at the beginning of the coronary angiography by using the arterial sheat in place.
Primary outcome measures
- Platelet GARP expression [Time frame: Throughout the entire study, approximately during 2 years]
Secondary outcome measures (1)
- Inflammatory profile [Time frame: Throughout the entire study, approximately during 2 years]
Eligibility criteria
Inclusion criteria
- Older than 18 years
- Able to give informed consent
- Undergoing coronary angiography.
Exclusion criteria
- Patients younger than 18 years
- Unable to give consent
- Pregnancy
- Dialysis
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
Belgium · 1 center
- Cliniques Universitaires Saint-Luc — Brussels
Identifiers
NCT: NCT07384910 · GARP-CS