Periodontal Status and Disease Severity in Pemphigus Vulgaris Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Clinical Periodontal and Oral Evaluation.
- Who it may be relevant to
- Registry conditions: Pemphigus Vulgaris (PV), Periodontal Diseases. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Clinical Investigation of the Relationship Between Disease Severity and Periodontal Status in Patients With Pemphigus Vulgaris
Overview
The aim of this study is to evaluate the relationship between the severity of Pemphigus Vulgaris (a chronic autoimmune skin disease) and periodontal (gum) health. Researchers will assess disease activity using the Oral Disease Severity Score (ODSS) for mouth lesions and measure serum Desmoglein 1 and 3 levels through blood tests. These findings will be compared with clinical gum measurements, such as pocket depth and attachment levels. The study intends to determine how the clinical and biochemical severity of Pemphigus Vulgaris impacts periodontal tissues and overall oral health.
Interventions
- Other Clinical Periodontal and Oral Evaluation
"Participants will undergo a comprehensive oral examination. The severity of oral mucosal involvement will be recorded using the Oral Disease Severity Score (ODSS). Clinical periodontal parameters, including Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL), will be measured at six sites per tooth using a periodontal probe. Additionally, current serum Desmoglein 1 and 3 levels will be retrieved from the patients' medical records for clinical correlation."
Primary outcome measures
- Oral Disease Severity Score (ODSS) [Time frame: Baseline]
Secondary outcome measures (5)
- Serum Desmoglein 1 and 3 Levels [Time frame: Baseline]
- Clinical Attachment Level (CAL) [Time frame: Baseline]
- Probing Pocket Depth (PPD) [Time frame: Baseline]
- Plaque Index (PI) [Time frame: Baseline]
- Gingival Index (GI) [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
- Patients aged 18 years and older.
- Clinically and histopathologically confirmed diagnosis of Pemphigus Vulgaris.
- Presence of at least 10 natural teeth.
- Willingness to participate and signed informed consent.
Exclusion criteria
- Pregnancy or lactation.
- Use of systemic antibiotics or anti-inflammatory drugs within the last 3 months.
- Periodontal treatment received within the last 6 months.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Turkey (Türkiye) · 1 center
- University of Health Sciences, Gulhane Faculty of Dentistry, Department of Periodontology — Ankara
Identifiers
NCT: NCT07384221 · 2025-161