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Not yet recruiting NCT07381699

MRG003 Combined With Immunotherapy in Recurrent/Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial

Phase II Interventional Nasopharyngeal Cancinoma (NPC)

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Becotatug Vedotin and Pucotenlimab.
Who it may be relevant to
Registry conditions: Nasopharyngeal Cancinoma (NPC). Basic parameters: 18 years — 75 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Becotatug Vedotin Plus Pucotenlimab as First-line Therapy in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial

Overview

This study was designed to compare the efficacy and safety of Becotatug Vedotin (MRG003) combined with Pucotenlimab as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma.

Interventions

  • Drug Becotatug Vedotin and Pucotenlimab
    Becotatug Vedotin (2.0mg/kg, ivgtt, every 3 weeks, D1) combined with Pucotenlimab (200mg, ivgtt, every 3 weeks, D1) is administered until disease progression (PD), unacceptable toxicity, or death.

Primary outcome measures

  • Progression Free Survival (PFS) [Time frame: Up to approximately 2 years.]
Secondary outcome measures (5)
  • Objective Response Rate (ORR) [Time frame: Up to approximately 2 years.]
  • The proportion of patients who achieved disease control [Time frame: Up to approximately 2 years.]
  • Duration of Response (DoR) [Time frame: Up to approximately 2 years.]
  • Overall Survival (OS) [Time frame: Up to approximately 2 years.]
  • Incidence of adverse events [Time frame: Up to approximately 2 years.]

Eligibility criteria

Inclusion criteria

  • Aged 18 to 75 years on the day of signing the informed consent form (or the legal age of consent in the jurisdiction in which the study is taking place).
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
  • Life expectancy ≥ 3 months.
  • Histologically or cytologically confirmed nasopharyngeal carcinoma (NPC).
  • Metastatic NPC (Stage IVB, AJCC 8th) or locally recurrent NPC unfit for curative local therapy (e.g., surgery, TACE, radiotherapy).
  • Must be treatment-naive for recurrent or metastatic NPC.
  • Must have ≥ 1 measurable lesions as defined per RECIST v1.1.
  • Adequate organ function.
  • For women of childbearing potential: negative pregnancy test within 7 days prior to treatment initiation. All participants of childbearing potential must agree to use effective contraception during the study and for 1 year after treatment discontinuation.
  • Willing and able to provide written informed consent and comply with study procedures and follow-up visits.

Exclusion criteria

  • Peripheral neuropathy of Grade 2 or higher.
  • Anticipated need for any other local or systemic anti-tumor therapy during the study period.
  • Diagnosed and/or treated additional malignancy within 5 years of enrollment, with the exception of curatively-treated basal cell or squamous cell carcinoma of the skin, and/or curatively-resected in situ cervical and/or breast carcinoma.
  • Active central nervous system (CNS) metastases or carcinomatous meningitis.
  • Laboratory values within 7 days prior to enrollment falling outside specified eligibility ranges (e.g., Child-Pugh C; creatinine clearance <30 mL/min; serum sodium <135 mmol/L; serum potassium <3.5 mmol/L).
  • Severe or uncontrolled cardiovascular disease.
  • History of or current interstitial lung disease, severe chronic obstructive pulmonary disease with respiratory failure, severe pulmonary insufficiency, or symptomatic bronchospasm.
  • Active infection requiring systemic therapy.
  • Severe, or uncontrolled systematic diseases (e.g., uncontrolled hypertension, or uncontrolled diabetes).
  • Known history of testing positive for human immunodeficiency virus (HIV).
  • Known history of allogeneic hematopoietic stem cell, bone marrow, or solid organ transplantation.
  • Known active hepatitis B or C infection, or other severe liver disease.
  • Live vaccine within 30 days prior to the first dose.
  • Residual toxicity from prior anti-tumor therapy higher than grade 1 (except alopecia, fatigue, and grade 2 hypothyroidism).
  • Active autoimmune disease or a history of autoimmune disease requiring systemic steroid or immunosuppressive therapy. The following conditions are not exclusionary: mild asthma controlled with intermittent bronchodilators; stable hypothyroidism on hormone replacement; vitiligo; Graves' disease; or Hashimoto's disease.
  • Known history of Grade 3 or higher hypersensitivity to any component of MRG003 or to other monoclonal antibodies.
  • Uncontrolled pleural effusion, ascites, or pericardial effusion.
  • Pregnancy, breastfeeding, or unwillingness to use a highly effective method of contraception during the treatment period and for at least 180 days after the last dose.
  • Any other condition that, in the opinion of the investigator, may compromise the safety and integrity of the study participant.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Treatment

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT07381699 · WCH-2026-NPC-PII-MRG003

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗