Effects of Weekly Set Volume on Muscle Adaptation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Low volume (LV), Moderate Volume (MV), High Volume (HV).
- Who it may be relevant to
- Registry conditions: Muscle Performance, Resistance Training. Basic parameters: 65 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Brazil
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Effect of Weekly Set Volume of Resistance Training on Strength and Hypertrophy
Overview
The progressive loss of strength and muscle mass is a natural aging process, with direct implications for functional capacity. Resistance training (RT) is considered the main intervention to counteract this decline. Although the RT guidelines are well established, the ideal weekly set volume to maximize strength and hypertrophy gains in older adults remains unknown. The purpose of this study is to investigate the effects of different volumes of weekly sets of RT on muscle strength and hypertrophy in older adults
Detailed description
BACKGROUND: The progressive loss of strength and muscle mass is a natural process of aging, with direct implications for functional capacity. Resistance training (RT) is considered the main intervention to counteract this decline. Although RT guidelines are well established, the ideal weekly volume of sets to maximize strength and hypertrophy gains in older adults remains unknown. PURPOSE: To investigate the effects of different weekly RT volumes on lower limb muscle strength and hypertrophy (quadriceps femoris) in older adults. METHODS: Fifty-seven older adults of both sexes will be matched for maximum dynamic strength (one repetition maximum - 1RM) and randomly divided into 03 groups: \[Low Volume (LV = 6 sets/week, n = 19), Moderate Volume (MV = 18 sets/week, n = 19) and High Volume (LV = 30 sets/week, n = 18)\]. All participants will undergo a 10-week resistance training protocol (3x/week), consisting of 8 exercises: bench press, leg press, seated row, leg extension, bicep curl, leg curl, triceps pulley, and seated calf raise. Only the leg extension and leg press exercises will be performed with different volumes of sets (VB = 1 set/exercise; VM = 3 sets/exercise; VA = 5 sets/exercise). The number of repetitions per set will be 8-12, and the training load will be adjusted every two weeks based on the maximum number of repetitions performed in the last training session. The following dependent variables will be analyzed before and after the training program: (1) maximum dynamic strength (1RM) and (2) maximum voluntary isometric contraction (MVIC) in the leg extension exercise, (3) muscle hypertrophy (thickness) of the quadriceps muscle and rectus femorisusing ultrasound images, and (4) rating of perceived exertion (RPE) and (5) affective responses (pleasure and displeasure) after training sessions. Data will be tested for normality and homogeneity using the Shapiro-Wilk's and Levene's tests, respectively. Changes over time and between groups will be analyzed with two-way repeated measures ANOVA tests. Violation of sphericity was corrected using the Greenhouse-Geisser method. When significant differences will be confirmed with the ANOVA, multiple comparison testing will be performed using the Bonferroni post hoc correction to identify these differences. Values will be expressed as mean (standard deviation and 95% confidence interval). The significance level was set at p \< 0.05.
Interventions
- Other Low volume (LV)
Participants will be performed 6 sets/week during 10 weeks - Other Moderate Volume (MV)
Participants will be performed 18 sets/week during 10 weeks - Other High Volume (HV)
Participants will be performed 30 sets/week during 10 weeks
Primary outcome measures
- Maximum dynamic strength (1RM) [Time frame: baseline and after 10 weeks of intervention]
- Maximum voluntary isometric contraction (MVIC) [Time frame: baseline and after 10 weeks of intervention]
- Muscle hypertrophy (thickness) [Time frame: baseline and after 10 weeks of intervention]
Secondary outcome measures (2)
- Rating of perceive exterion (RPE) [Time frame: Immediately after completion of each set of exercise]
- Affective responses (pleasure and displeasure) [Time frame: Immediately after each exercise during training sessions]
Eligibility criteria
Inclusion criteria
- Age between 65 and 80 years
Exclusion criteria
- not having used any medication or substance that affects or improves muscle function for at least 3 months prior to the study,
- having any physical or physiological limitation that may affect the ability to perform the tests and physical training,
- not being able to understand the informed consent form and study procedures.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
Brazil · 1 center
- Northern University of Paraná — Londrina
Publications
- Robertson RJ, Goss FL, Rutkowski J, Lenz B, Dixon C, Timmer J, Frazee K, Dube J, Andreacci J. Concurrent validation of the OMNI perceived exertion scale for resistance exercise. Med Sci Sports Exerc. 2003 Feb;35(2):333-41. doi: 10.1249/01.MSS.0000048831.15016.2A. PMID 12569225
Identifiers
NCT: NCT07379385 · Weekly set volume study