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Recruiting NCT07379216

Efficacy Evaluation Study of Vitamin C and Glutathione Liquid Sachet

No phase Interventional Skin Condition Anti-Oxidative Stress

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Placebo sachet, Vitamin C and Glutathione Liquid Sachet.
Who it may be relevant to
Registry conditions: Skin Condition, Anti-Oxidative Stress. Basic parameters: 18 years — 65 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Taiwan
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

The objective of this study is to evaluate the effect of liquid vitamin C and glutathione supplements on human skin condition improvement and anti-oxidation.

Detailed description

This study is a single-center, placebo-controlled, double-blinded, parallel human trial designed to evaluate the skin beauty and anti-oxidant effect of liquid vitamin C and glutathione supplements.

Healthy adult participants aged 18-65 years will be enrolled. Participants will be informed to consume test samples daily for 12 consecutive weeks. Skin measurement and self-assessment questionnaires will be conducted at baseline (before intake), after 4, 8 weeks, and 12 weeks of consumption. Fasting blood samples will be collected at baseline and after 12 weeks of consumption.

Interventions

  • Dietary supplement Placebo sachet
    consume 1 sachet of the test samples daily for 12 consecutive weeks
  • Dietary supplement Vitamin C and Glutathione Liquid Sachet
    consume 1 sachet of the test samples daily for 12 consecutive weeks

Primary outcome measures

  • The change of skin tone [Time frame: Change from Baseline skin tone at 12 weeks]
  • The change of visible spots [Time frame: Change from Baseline visible spots at 12 weeks]
  • The change of UV spots [Time frame: Change from Baseline UV spots at 12 weeks]
Secondary outcome measures (12)
  • The change of skin hydration [Time frame: Change from Baseline skin hydration at 12 weeks]
  • The change of skin redness [Time frame: Change from Baseline skin redness at 12 weeks]
  • The change of skin melanin index [Time frame: Change from Baseline skin melanin index at 12 weeks]
  • The change of skin elasticity [Time frame: Change from Baseline skin elasticity at 12 weeks]
  • The change of brown spots [Time frame: Change from Baseline brown spots at 12 weeks]
  • The change of wrinkles around the eyes [Time frame: Change from Baseline wrinkles around the eyes at 12 weeks]
  • The change of skin texture [Time frame: Change from Baseline skin texture at 12 weeks]
  • The change of skin collagen density [Time frame: Change from Baseline skin collagen density at 12 weeks]
  • The change of total antioxidation capacity (TAC) [Time frame: Change from Baseline TAC at 12 weeks]
  • The change of Superoxide Dismutase (SOD) [Time frame: Change from Baseline SOD at 12 weeks]
  • The change of Glutathione S-transferase-Red Blood Cells (GST-RBC) [Time frame: Change from Baseline GST-RBC at 12 weeks]
  • The change of Malondialdehyde (MDA) [Time frame: Change from Baseline MDA at 12 weeks]

Eligibility criteria

Inclusion criteria

  • Healthy male or female adults, aged 18-65 years old;
  • Commitment not to use products having activity comparable with that of the product to be tested during the study period;
  • Free of any dermatological or systemic disorder that would interfere with results.

Exclusion criteria

  • Subject with obvious skin surface damage;
  • Subject who had oral or topical medication which may affect skin condition within 1 month;
  • Individuals with known allergies to cosmetics, medications, or foods (especially those allergic to legumes/soy);
  • Pregnant or breastfeeding individuals;
  • Received facial laser therapy, chemical peeling in the past 2 months.
  • Individuals unwilling to allow publication or public disclosure of photographs taken as part of the study results

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Double blind
Primary purpose
Treatment

Study locations

Taiwan · 1 center
  • Chia Nan University of Pharmacy & Science — Pingtung City

Identifiers

NCT: NCT07379216 · 25-103-A

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗