Low Versus High Load Training and Parkinson's Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Low-Load Resistance Training, High-Load Resistance Training.
- Who it may be relevant to
- Registry conditions: Activity, Motor. Basic parameters: 50 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Comparison of Changes in Neuromuscular and Functional Performance Due to Resistance Training With Low-Load or High-Load in Persons With Parkinson's Disease.
Overview
This study will compare the effects of high-load resistance training to low-load resistance training, on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.
Interventions
- Behavioral Low-Load Resistance Training
Participants will receive a total of twenty-four 45-minutes in-person training sessions, twice per week using three sets of eight repetitions per set. During training participants will be allowed 2-minute rests between sets. Exercises will include four upper-body exercises and two lower-body exercises. - Behavioral High-Load Resistance Training
Participants will receive a total of twenty-four 45-minutes in-person training sessions, twice per week using four sets of eight repetitions per set. During training participants will be allowed 2-minute rests between sets. Exercises will include four upper-body exercises and two lower-body exercises.
Primary outcome measures
- Change in neuromuscular performance as measured by 1-repetition maximum (1RM) [Time frame: [Time Frame: Baseline, 12 weeks]]
- Change in neuromuscular performance as measured by Power Production [Time frame: Baseline, 12 weeks]
Secondary outcome measures (4)
- Change in the Speed of the Ten-Meter Walk Test. [Time frame: Baseline, 12 weeks]
- Change in Time for the Five Times Sit-to-Stand Test. [Time frame: Baseline, 12 weeks]
- Change in the time required to complete the timed Up-and-Go Test. [Time frame: Baseline, 12 weeks]
- Change in Distance of the Seated Medicine Ball Throw. [Time frame: Baseline, 12 weeks]
Eligibility criteria
Inclusion criteria
- Parkinson's Disease Hoehn \& Yahr Stages 1-3
- Able to walk 50m unassisted
- Able to understand and communicate in English
- A Montreal Cognitive Assessment (MoCA) score above 18
Exclusion criteria
- Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
- Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
- Unresolved injury or surgery to the upper or lower limbs that prevents weight training.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United States · 1 center
- Laboratory of Neruomuscular Research and Active Aging — Coral Gables
Identifiers
NCT: NCT07378813 · 20251268