Macrophage/Monocyte Driven Inflammation and Anesthetic Sensitivity in Aging
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Aging, Inflammation, Blood-Brain Barrier Permeability, Anesthesia Brain Monitor. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Chile
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Role of Macrophage/Monocyte Mediated Inflammatory Response in Diminished Anesthetic Requirements During Aging
Overview
The goal of this observational study is to determine whether macrophage/monocyte mediated inflammatory signaling contributes to reduced anesthetic requirements in older adults undergoing major abdominal surgery. The main questions it aims to answer are: * Is there a difference in anesthetic dosing requirements (minimum effective dose) between young and older patients undergoing major abdominal surgery? * How do electroencephalographic (EEG) signatures under anesthesia correlate with age and systemic inflammatory markers? * Is there an association between age, levels of circulating inflammatory cytokines, and monocyte/macrophage phenotypes with anesthetic requirements? If there is a comparison group: Researchers will compare older adult patients undergoing major abdominal surgery to younger adult patients undergoing major abdominal surgery to see if macrophage/monocyte-mediated inflammatory signaling influences anesthetic sensitivity and the risk of postoperative neurocognitive complications in the older population. Participants will: * Receive general anesthesia for major abdominal surgery, with continuous recording of anesthetic dose requirements. * Undergo electroencephalographic (EEG) monitoring during the anesthetic period. * Provide blood samples for the measurement of circulating inflammatory cytokines and the assessment of monocyte phenotypes. * Provide peritoneal tissue samples (collected during surgery) to evaluate tissue macrophage populations. * Provide cerebrospinal fluid (CSF) samples to assess biomarkers of blood-brain barrier permeability.
Primary outcome measures
- Frontal EEG alpha-band power [Time frame: Perioperative]
Secondary outcome measures (6)
- Time-to-loss of consciousness [Time frame: Perioperative]
- Intraoperative anesthetic requirements [Time frame: Perioperative]
- Time to emergence [Time frame: Perioperative]
- Cytokine circulating profile [Time frame: Baseline]
- Monocyte/Macrophage phenotype in blood and peritoneal samples [Time frame: Periprocedural]
- Blood-brain barrier permeability [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
- Age between 18-30 years or over 60 years old
- Scheduled for abdominal surgery
- General anesthesia planned with or without spinal anesthesia
- Able and willing to provide written informed consent.
Exclusion criteria
- Chemotherapy or systemic corticosteroid use within the past 2 weeks.
- Pregnancy.
- Active sepsis or systemic infection.
- Emergency surgery.
- Requirement of ketamine or dexmedetomidine during the first hour of anesthesia.
- History or diagnosis of: stroke with persistent neurological deficit, dementia, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, central nervous system autoimmune disorders, systemic autoimmune diseases, or infectious diseases of the central nervous system.
- Current treatment with immunomodulatory medications.
- Psychiatric disorders with psychotic features.
- Use of psychoactive or psychotropic recreational drugs within the week prior to surgery.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Chile · 1 center
- Hospital Clínico Universidad de Chile — Santiago
Identifiers
NCT: NCT07372417 · OAIC N°1538/25