Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass Reduction
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Genotype-Based Dietary Counseling, Standard Dietary Counseling.
- Who it may be relevant to
- Registry conditions: Overweight, Overweight and Obesity, Adiposity. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Greece
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study aims to compare the effects of genotype-based dietary counseling with standard dietary counseling based on general recommendations on weight loss and reduction of body fat. Participants will receive individualized dietary guidance either informed by genetic information or based on conventional dietary guidelines. Changes in body weight and body composition will be assessed over the course of the intervention.
Interventions
- Behavioral Genotype-Based Dietary Counseling
This intervention consists of dietary counseling informed by individual genetic information. Nutrition guidance is provided by qualified nutrition professionals and aims to support weight management and reduction of body fat over the intervention period. - Behavioral Standard Dietary Counseling
This intervention consists of dietary counseling based on general dietary guidelines and standard nutrition recommendations. Counseling is delivered by qualified nutrition professionals without the use of genetic information.
Primary outcome measures
- Change in Fat Mass (%) [Time frame: baseline to end of intervention (12 months)]
Secondary outcome measures (2)
- Change in Body Weight [Time frame: baseline to end of intervention (12 months)]
- Change in Lipid Profile [Time frame: baseline to end of intervention (12 months)]
Eligibility criteria
Inclusion criteria
- Adults aged ≥18 years
- Body mass index (BMI) ≥25 kg/m²
- Greek-speaking (able to read and understand Greek and provide informed consent)
- Willing and able to participate in dietary counseling and study assessments for the duration of the study
Exclusion criteria
- Current use of pharmacological treatments for weight loss, including but not limited to GLP-1 receptor agonists, appetite suppressants, or other anti-obesity medications
- Participation in any structured weight-loss intervention or program within the previous 3 months, including commercial weight-loss programs or medically supervised dietary interventions
- Use of medications known to significantly affect body weight or body composition, such as systemic corticosteroids, antipsychotic medications, or medications for thyroid disorders
- Pregnancy or lactation
- Presence of medical conditions that may affect body weight, metabolism, or nutritional status, including untreated thyroid disease, severe gastrointestinal disorders, or endocrine disorders
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Other
Study locations
Greece · 1 center
- Dietetics Department, School of Health Sciences, Metropolitan College — Marousi
Identifiers
NCT: NCT07368777 · 001