Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age.
- Who it may be relevant to
- Registry conditions: Down Syndrome. Basic parameters: 1 year — 6 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Relationship Between Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis
Overview
Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age
Detailed description
descriptive, cross-sectional study analyzed baseline data from 40 children with DS and acute pneumonia enrolled prior to intervention in a larger trial. Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age.
Interventions
- Procedure Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age
Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age.
Primary outcome measures
- serum IgG, IgA, IgM [Time frame: Upon enrollment and prior to any intervention baseline data were collected]
- Respiratory Rate [Time frame: Upon enrollment and prior to any intervention baseline data were collected]
- Arterial Oxygen Saturation (SaO2) [Time frame: Upon enrollment and prior to any intervention baseline data were collected]
- White Blood Cell count [Time frame: Upon enrollment and prior to any intervention baseline data were collected]
Eligibility criteria
Inclusion criteria
- Down Syndrome with acute bronchopneumonia
- sufficient cognitive ability
Exclusion criteria
- severe congenital heart defects
- primary immunodeficiencies
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
Egypt · 2 centers
- Badr university — Cairo
- Mona Mohamed Abdelkhalek — Cairo
Identifiers
NCT: NCT07366593 · Down Syndrome Children