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Recruiting NCT07360249

Glucose-fructose Ratio Pilot

No phase Interventional Exercise Metabolism

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Glucose and fructose (one-to-one), Glucose and fructose (two-to-one).
Who it may be relevant to
Registry conditions: Exercise Metabolism. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United Kingdom
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

PILOT TEST OF GLUCOSE-FRUCTOSE RATIOS ON EXOGENOUS CARBOHYDRATE OXIDATION RATES DURING EXERCISE

Overview

The aim of this pilot study is to estimate the effect size of changing the glucose-fructose ratio from 1:0.5 to 1:1 on exogenous carbohydrate oxidation rates during exercise, which can be used to power a future definitive study.

Interventions

  • Other Glucose and fructose (one-to-one)
    Glucose and fructose ingested in solution in a one-to-one ratio (135 grams per hour for 3 hours during exercise)
  • Other Glucose and fructose (two-to-one)
    Glucose and fructose ingested in solution in a two-to-one ratio (135 grams per hour for 3 hours during exercise)

Primary outcome measures

  • Exogenous carbohydrate oxidation rate (g/h) [Time frame: 180 minutes]
Secondary outcome measures (8)
  • Peak exogenous carbohydrate oxidation rate (g/h) [Time frame: 180 minutes]
  • Whole-body carbohydrate oxidation rate (g/h) [Time frame: 180 minutes]
  • Endogenous carbohydrate oxidation rate (g/h) [Time frame: 180 minutes]
  • Whole-body fat oxidation rate (g/h) [Time frame: 180 minutes]
  • Blood lactate concentrations (mmol/L) [Time frame: 180 mninutes]
  • Blood glucose concentrations (mmol/L) [Time frame: 180 minutes]
  • Ratings of gut comfort (arbitrary units) [Time frame: 180 minutes]
  • Ratings of perceived exertion (arbitrary units) [Time frame: 180 minutes]

Eligibility criteria

Inclusion criteria

  • Age: 18 years and above;
  • Performing endurance training for at least 5 hours per week
  • Capable of three hours of continuous exercise

Exclusion criteria

  • Glucose or lipid lowering, or weight loss medication
  • Diagnosis of cardiovascular disease, renal failure, liver disease or type 2 diabetes
  • Contraindications to exercise
  • Pregnant or lactating

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Crossover
Masking
Triple blind
Primary purpose
Basic science

Study locations

United Kingdom · 1 center
  • University of Bath — Bath

Identifiers

NCT: NCT07360249 · 11030

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗