Prospective Familial Registry for Pancreas Research
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Family History of Pancreas Cancer. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Prospective Familial Cohort for Pancreas Research
Overview
The purpose of this research is to develop a resource registry of individuals currently without pancreatic cancer but are members of a kindred with two or more blood-related family members with pancreas cancer.
Detailed description
If you agree to be in the study, you will be asked to fill out a questionnaire once every two years. The questionnaire will ask you questions about your health and family history. The investigator may ask you to donate a one-time blood specimen of approximately 3½ tablespoons, which can be done at your local doctor's office. The investigator may ask you if you are willing to provide the names and addresses of other family members who may be eligible to participate in the study. No visits to Mayo Clinic are required for your participation.
Primary outcome measures
- To establish a prospective cohort of individuals from pancreas cancer families [Time frame: 25 years]
- Change in health [Time frame: 25 years]
Eligibility criteria
Inclusion criteria
- An individual who was previously enrolled in Mayo Clinic IRB # 1197-00, 354-06, 355-06, or 19-010791
- Is age 18 years or older.
- Has a valid United States mailing address.
- Has at least two blood-related relatives who have had pancreas cancer or has a blood-relative with pancreatic cancer and that relative carries a known germline mutation in APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, TP53 or mutations in other genes known to be associated with pancreatic cancer.
Exclusion criteria
- An individual who is a prison inmate
- An individual who is not compos mentis (of sound mind, memory, and understanding), and not able to give consent.
- Has personal history of pancreas cancer.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- Mayo Clinic — Rochester
Identifiers
NCT: NCT07358208 · 25-002416