Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School Children
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Probiotic mouthwash, Ethyl lauroyl arginate mouthwash, Professional prophylaxis (scaling + polishing).
- Who it may be relevant to
- Registry conditions: Probiotic, Ethyl Lauroyl Arginate, Mouthwashes, Streptococcus Mutans. Basic parameters: 6 years — 12 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Comparative Evaluation of Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School Children: A Randomized Controlled Clinical Trial
Overview
This study aims to compare the efficacy of probiotic-based mouthwashes versus ethyl lauroyl arginate-containing mouthwashes in reducing Streptococcus mutans count, dental plaque accumulation, and salivary pH among a group of Egyptian schoolchildren.
Detailed description
Dental caries remains one of the most prevalent chronic infectious diseases among Egyptian schoolchildren, with Streptococcus mutans (S. mutans) playing a primary etiological role due to its acidogenic and aciduric properties, which contribute to enamel demineralization and plaque formation.
Ethyl Lauroyl Arginate (LAE), a cationic surfactant derived from lauric acid and arginine, has demonstrated potent bactericidal activity against cariogenic organisms, including S. mutans, while also reducing biofilm formation and preserving oral microbiome balance.
Interventions
- Other Probiotic mouthwash
Patients will be receive probiotic mouthwash and instructed to rinse 5ml twice daily for 30 seconds for 28 days. - Other Ethyl lauroyl arginate mouthwash
Patients will be treated with ethyl lauroyl arginate mouthwash and instructed to rinse 5ml twice daily for 30 seconds for 28 days. - Other Professional prophylaxis (scaling + polishing)
Patients will receive professional prophylaxis (scaling + polishing) at baseline and will use only regular toothpaste twice daily, with no adjunctive mouthwashes over 28 days.
Primary outcome measures
- S. mutans count [Time frame: 28 days post-intervention]
Secondary outcome measures (2)
- Plaque index score [Time frame: 28 days post-intervention]
- Salivary pH [Time frame: 28 days post-intervention]
Eligibility criteria
Inclusion criteria
- Healthy Egyptian schoolchildren aged 6-12 years.
- Good general health.
- Mild to moderate dental plaque accumulation.
- Parental/caregiver willingness to provide consent
Exclusion criteria
- Antibiotic or antimicrobial use within the last month.
- Allergies to the mouthwash components.
- Systemic diseases affecting oral health.
- Orthodontic appliances or extensive dental restorations.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Al-Azhar University (Faculty of Dentistry) — Cairo
Identifiers
NCT: NCT07356869 · 1246/4697