Remission in Adults With Mild-to-moderate Asthma in Thailand
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Global Initiative for Asthma (GINA) and Asthma Control Test (ACT) questionnaires, Spirometry, Fractional exhaled nitric oxide (FeNO) test, Blood eosinophil count (BEC).
- Who it may be relevant to
- Registry conditions: Asthma, Mild-to-moderate Asthma, Asthma Control Level. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Thailand
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The goal of this observational study is to determine the prevalence of remission among adults with mild-to-moderate asthma, as well as the factors associated with remission in Thailand. The main question the study aims to answer is: What is the prevalence of remission among adults with severe asthma in Thailand? Participants will complete a questionnaire on asthma symptoms and undergo pulmonary function testing and a blood test once.
Detailed description
This study is a cross-sectional study. Thai patients aged 18 years or older with mild-to-moderate asthma are included in the study. Participants will complete two questionnaires about asthma control: the Global Initiative for Asthma (GINA) and the Asthma Control Test (ACT), and will perform spirometry, a fractional exhaled nitric oxide (FeNO) test, and blood eosinophil counts (BEC).
GINA and ACT are questionnaires used to assess the level of asthma control.
Interventions
- Other Global Initiative for Asthma (GINA) and Asthma Control Test (ACT) questionnaires
GINA and ACT are questionnaires used to assess the level of asthma control. - Other Spirometry
Spirometry is a tool used to assess pulmonary function. - Other Fractional exhaled nitric oxide (FeNO) test
FeNO is a tool used to assess eosinophilic airway inflammation and asthma remission. - Other Blood eosinophil count (BEC)
BEC is a tool used to assess eosinophilic inflammation and asthma remission.
Primary outcome measures
- Prevalence rate of mild-to-moderate asthma remission [Time frame: An average of 1 year]
Secondary outcome measures (5)
- Asthma control in patients with mild-to-moderate asthma [Time frame: At baseline and at 12 months]
- Airway obstruction in patients with mild-to-moderate asthma [Time frame: At baseline and at 12 months]
- Severity of aiway obstruction in patients with mild-to-moderate asthma [Time frame: At baseline and at 12 months]
- Eosinophil airway inflammation in patients with mild-to-moderate asthma [Time frame: At baseline and at 12 months]
- Type 2 airway inflammation in patients with mild-to-moderate asthma [Time frame: At baseline and at 12 months]
Eligibility criteria
Inclusion criteria
- mild-to-moderate asthma
- age 18 years or older
Exclusion criteria
- inability to perform spirometry or fractional exhaled nitric oxide (FeNO) test
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Thailand · 2 centers
- Narongkorn Saiphoklang — Pathum Thani
- Faculty of Medicine, Thammasat University — Pathum Thani
Publications
- Ishizuka M, Sugimoto N, Kobayashi K, Takeshita Y, Imoto S, Koizumi Y, Togashi Y, Tanaka Y, Nagata M, Hattori S, Uehara Y, Suzuki Y, Toyota H, Ishii S, Nagase H. Clinical remission of mild-to-moderate asthma: Rates, contributing factors, and stability. J Allergy Clin Immunol Glob. 2025 Jan 30;4(2):100431. doi: 10.1016/j.jacig.2025.100431. eCollection 2025 May. PMID 40091885
- Holm M, Omenaas E, Gislason T, Svanes C, Jogi R, Norrman E, Janson C, Toren K; RHINE Study Group. Remission of asthma: a prospective longitudinal study from northern Europe (RHINE study). Eur Respir J. 2007 Jul;30(1):62-5. doi: 10.1183/09031936.00121705. Epub 2007 Mar 14. PMID 17360725
- Tupper OD, Hakansson KEJ, Ulrik CS. Remission and Changes in Severity Over 30 Years in an Adult Asthma Cohort. J Allergy Clin Immunol Pract. 2021 Apr;9(4):1595-1603.e5. doi: 10.1016/j.jaip.2020.11.013. Epub 2020 Nov 19. PMID 33220516
- Chiewchalermsri C, Kanjanawasee D, Saiphoklang N, Chirakalwasan N, Sriprasart T, Senavonge A, Sanguanwong N, Kamalaporn H, Athipongarporn A, Hachai S, Boonsawat W, Brannan JD, Song WJ, Ruxrungtham K, Poachanukoon O. Asthma remission: A path to cure? Asian Pac J Allergy Immunol. 2025 Jun;43(2):135-150. doi: 10.12932/AP-240525-2082. PMID 40652405
Identifiers
NCT: NCT07351916 · MTU-EC-IM-0-282/68