Recruiting NCT07351903
A Single-arm, Open-label Study of GK01 in Combination With or Without Chemotherapy for the Adjuvant Treatment of Solid Tumors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: GK01 Injection.
- Who it may be relevant to
- Registry conditions: Solid Tumors. Basic parameters: 18 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Single-arm Open-label Clinical Study Evaluating the Use of GK01 Cell Injection in Combination With or Without Chemotherapy for the Adjuvant Treatment of Solid Tumors
Overview
This study is an open-label, single-arm clinical trial to evaluate the safety, pharmacokinetics, and preliminary efficacy of GK01 in patients with advanced solid tumors.
Interventions
- Drug GK01 Injection
Autologous tumor-reactive T cells injection
Primary outcome measures
- Safety and Tolerability [Time frame: 2 years]
Secondary outcome measures (5)
- PK [Time frame: 2 years]
- Recurrence free survival(RFS) [Time frame: 2 years]
- Overall survival (OS ) [Time frame: 2 years]
- Patient Quality of Life [Time frame: 2 years]
- PD marker [Time frame: 2 years]
Eligibility criteria
- Ability to understand and sign a written informed consent document.
- At the date of signing ICF, 18 \~70 years old, male or female.
- Patients with solid tumors confirmed by histopathology (including but not limited to pancreatic cancer, cholangiocarcinoma, gastric cancer, etc.) who are judged by investigator to be capable of undergoing radical total resection of the primary tumor for the purpose of cure.
- No treatment for the primary tumor was received before surgical resection (no induction therapy or recurrent disease).
- The expected survival time is more than 12 weeks;.
- ECOG 0-1 points.
Exclusion criteria
- Inoperable or metastatic (Stage IV) solid tumors.
- Central nervous system (CNS) metastasis, leptomeningeal disease, or metastatic spinal cord compression; or a history of CNS disorders, including but not limited to epilepsy, paralysis, aphasia, stroke, severe brain injury, dementia, Parkinson's disease, etc.
- History of bone marrow or solid organ transplantation.
- History of other primary malignancies within 5 years prior to study treatment
- Hepatitis B surface antigen (HBsAg) positivity; With negative HBsAg but positive hepatitis B core antibody (HBcAb) ,and if peripheral blood hepatitis B virus (HBV) DNA positive; Hepatitis C virus (HCV) antibody positive and HCV RNA positive; Human immunodeficiency virus (HIV) antibody positive; Cytomegalovirus (CMV) DNA positive; Both Treponema pallidum-specific and non-specific antibody tests are positive.
- Allergy to any components of the drugs planned.
- Previous radiotherapy within 28 days before signing the ICF.
- History of active tuberculosis infection within 1 year before screening.
- Concurrent or previous history of interstitial lung disease or interstitial pneumonia; presence of chronic lung disease or other respiratory conditions that significantly impair lung function.
- Diagnosis of active autoimmune disease or a history of autoimmune disease that may recur (e.g., systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vasculitis, psoriasis, etc.), or at risk of such conditions.
- Investigator-assessed clinically significant thyroid dysfunction.
- Cardiovascular diseases with clinical significance.
- No contraindications to curative resection of the primary tumor.
- Attenuated or inactivated vaccines within 28 days before signing the I form, or planned administration of such vaccines during the screening period.
- Comorbidities or other conditions are likely to affect protocol compliance or suitability for participation in this study.
- Female subjects who are pregnant or breastfeeding.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
China · 1 center
- Tianjin Cancer Hospital Airport Hospital — Tianjin
Identifiers
NCT: NCT07351903 · GUARDIAN-02