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Recruiting NCT07349173

Peripersonal Space Representation in Upper Limb Segmental Exclusion

— Observational Segmental Exclusion Syndrome Complex Regional Pain Syndrome (CRPS) Upper Limb Neglect (Peripheral)

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Reachability Judgment Task in VR..
Who it may be relevant to
Registry conditions: Segmental Exclusion Syndrome, Complex Regional Pain Syndrome (CRPS), Upper Limb Neglect (Peripheral). Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
France
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Study of the Representation of Action Peripersonal Space in Participants With Unilateral Segmental Exclusion of the Upper Limb Compared to Asymptomatic Subjects

Overview

This study aims to evaluate the representation of action peripersonal space (PPS) in subjects suffering from unilateral segmental exclusion syndrome of the upper limb compared to healthy control subjects. Segmental exclusion is defined by non-use or under-use of a limb segment without central nervous system damage. The study hypothesizes that this syndrome leads to a modification (shrinkage) of the PPS representation. Participants will perform reachability judgments in a Virtual Reality (VR) environment.

Detailed description

Segmental exclusion syndrome often occurs after limb trauma and manifests as a neglect-like behavior of peripheral origin, sometimes associated with Complex Regional Pain Syndrome (CRPS). The study explores whether the lack of limb use affects the representation of peripersonal space (PPS)-the space immediately surrounding the body where interactions with objects occur.

The study is monocentric, observational, with a matched control group. Participants will undergo:

Clinical assessment (questionnaires on pain, anxiety, body perception, and kinesiophobia).

A Virtual Reality (VR) test (approx. 40 minutes). In VR, participants will judge whether a cylinder presented at different distances and angles is reachable without moving (Perceived Reachable Distance - DMA-p). This will be compared to their Real Reachable Distance (DMA-r).

The goal is to measure the error of judgment to assess PPS representation and check for correlations with body schema disturbances or functional impairment

Interventions

  • Behavioral Reachability Judgment Task in VR.
    Participants wear an Oculus Quest 2 VR headset. They first perform a motor task to measure Real Reachable Distance (DMA-r). Then, they perform a perceptual task where they must judge, without moving, if a virtual object is reachable (DMA-p). The test evaluates different spatial planes (front, 45° right, 45° left) and heights (shoulder, navel).

Primary outcome measures

  • Judgment Error of Reachability [Time frame: Day 1 (During the 40-minute VR assessment)]
Secondary outcome measures (5)
  • Body Perception Disturbance Score [Time frame: Day 1 (Before VR task)]
  • Functional Impairment Score (400-Point Hand Assessment) [Time frame: Day 1]
  • Anxiety and Depression Score (HAD) [Time frame: Day 1]
  • Kinesiophobia Score (Tampa Scale) [Time frame: Day 1]
  • Pain Catastrophizing Score (PCS) [Time frame: Day 1]

Eligibility criteria

Inclusion Criteria (patients):

  • Age ≥ 18 years.
  • Presenting unilateral exclusion symptom of the upper limb or part of the hand evolving for > 3 months.
  • No contraindication to force work in daily activities.
  • For patients with finger exclusion: at least 2 perturbed items related to exclusion on tests 3 and 4 of the "Bilan 400 points".
  • Affiliated to a social security scheme.
  • Able to understand simple orders.

Inclusion Criteria (Controls):

  • Age ≥ 18 years.
  • No history of upper limb impairment with sequelae.

Exclusion Criteria (All):

  • Visual impairments.
  • Central neurological pathology.
  • Unstabilized psychiatric pathology.
  • Communication or comprehension difficulties.
  • Under legal protection or unable to consent.
  • Pregnant or breastfeeding women.
  • Cervical pathology contraindicating VR headset use.
  • Epilepsy.
  • Upper limb pathology unrelated to exclusion.
  • Inability to stand for 40 minutes.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Case-control

Study locations

France · 1 center
  • Institut Régional de Médecine Physique et de Réadaptation (IRR), Centre Louis Pierquin. — Nancy

Identifiers

NCT: NCT07349173 · IRR-CLP-2023-3 · 2025-A02189-40

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗